SCHEMBL28634940

SCHEMBL28634940

COC(=O)c1nnn(-c2ccc(C(C)(C)C)cc2)c1C

nearest known ligand 0.52

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TP53 P04637 2/20 0.52
ALOX12 P18054 1/20 0.52
MAPT P10636 1/20 0.52
KMT2A Q03164 2/20 0.51
MEN1 O00255 1/20 0.51
GAA P10253 1/20 0.51
PTGS2 P35354 5/20 0.49
HTT P42858 1/20 0.49
NR1I2 O75469 4/20 0.48
CA1 P00915 2/20 0.48
CA2 P00918 2/20 0.48
CA12 O43570 1/20 0.48
CA9 Q16790 1/20 0.48
ALDH1A1 P00352 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3406088 0.83 PTGS2 (0.71) TP53ALOX12MAPTKMT2AMEN1
SCHEMBL16698019 0.83 TP53 (0.55) TP53ALOX12MAPTKMT2AMEN1
SCHEMBL26732977 0.80 NR1I2 (0.73) TP53MAPTKMT2ANR1I2ALDH1A1
SCHEMBL22831608 0.74 SMN1; SMN2 (0.52) TP53MAPTKMT2AMEN1GAA
SCHEMBL2976397 0.73 NR1I2 (0.53) NR1I2
SCHEMBL26732920 0.71 NR1I2 (0.76) NR1I2
SCHEMBL15882211 0.71 SMN1; SMN2 (0.77) TP53ALOX12MAPTKMT2AALDH1A1
SCHEMBL27830486 0.71 CA1 (0.61) TP53KMT2AMEN1GAACA1
SCHEMBL17454416 0.70 PTGS2 (0.68) MAPTKMT2APTGS2HTTCA1
SCHEMBL15882034 0.70 HTT (0.69) TP53ALOX12MAPTKMT2APTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110015999-B Synthesis method of 1,2, 3-triazole compound 济南大学 2021-10-01 CN disclosed