Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | TOP2A | P11388 | 2/20 | 0.36 |
| ▸ | IKBKB | O14920 | 2/20 | 0.34 |
| ▸ | VDR | P11473 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 6/20 | 0.34 |
| ▸ | TP53 | P04637 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30703771 | 1.00 | KDM4E (0.41) | KDM4EHSD17B10PPARGNCOA2ALDH1A1 | |
| SCHEMBL30703864 | 0.86 | KDM4E (0.44) | KDM4EHSD17B10PPARGNCOA2ALDH1A1 | |
| SCHEMBL28652254 | 0.86 | KDM4E (0.44) | KDM4EHSD17B10PPARGNCOA2ALDH1A1 | |
| SCHEMBL30703825 | 0.78 | ALDH1A1 (0.36) | KDM4EHSD17B10PPARGNCOA2ALDH1A1 | |
| SCHEMBL22308216 | 0.78 | ALDH1A1 (0.53) | KDM4EHSD17B10PPARGALDH1A1HPGD | |
| SCHEMBL28647095 | 0.78 | ALDH1A1 (0.36) | KDM4EHSD17B10PPARGNCOA2ALDH1A1 | |
| SCHEMBL31521809 | 0.78 | ALDH1A1 (0.53) | KDM4EHSD17B10PPARGALDH1A1HPGD | |
| SCHEMBL21842992 | 0.75 | TP53 (0.44) | KDM4EHSD17B10ALDH1A1HPGDNPSR1 | |
| SCHEMBL23198773 | 0.72 | MAPT (0.54) | KDM4EHSD17B10ALDH1A1HPGDL3MBTL1 | |
| SCHEMBL20295983 | 0.70 | TOP2A (0.47) | KDM4EHSD17B10ALDH1A1HPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113348170-B | Biphenyl derivative inhibitor, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2023-12-22 | — | — | CN | disclosed |
| CN-113348170-A | Biphenyl derivative inhibitor, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2021-09-03 | — | — | CN | disclosed |