Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 17/20 | 0.42 |
| ▸ | MARK3 | P27448 | 3/20 | 0.41 |
| ▸ | NEK4 | P51957 | 3/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.41 |
| ▸ | CAMK2B | Q13554 | 3/20 | 0.41 |
| ▸ | CAMK2G | Q13555 | 3/20 | 0.41 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.41 |
| ▸ | MARK2 | Q7KZI7 | 3/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.41 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.41 |
| ▸ | MAP3K20 | Q9NYL2 | 3/20 | 0.41 |
| ▸ | MAP4K5 | Q9Y4K4 | 3/20 | 0.41 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.41 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.41 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.41 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.41 |
| ▸ | AXL | P30530 | 2/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19615152 | 0.90 | HTR6 (0.39) | MCL1MARK3NEK4PRKCDCAMK2B | |
| SCHEMBL23753189 | 0.84 | MCL1 (0.35) | MCL1MARK3NEK4PRKCDCAMK2B | |
| SCHEMBL28462841 | 0.84 | MCL1 (0.39) | MCL1MARK3NEK4PRKCDCAMK2B | |
| SCHEMBL19615324 | 0.81 | MCL1 (0.66) | MCL1MARK3NEK4PRKCDCAMK2B | |
| SCHEMBL21802166 | 0.76 | HTR6 (0.35) | MCL1MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL30922686 | 0.75 | JAK2 (0.34) | JAK2 | |
| SCHEMBL22437338 | 0.74 | HTR6 (0.35) | MEN1ALDH1A1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL22436710 | 0.74 | HTR6 (0.34) | MCL1MARK3NEK4PRKCDCAMK2B | |
| SCHEMBL19635394 | 0.74 | HTR6 (0.44) | MCL1KDM4EMEN1ALDH1A1GAA | |
| SCHEMBL28471098 | 0.74 | MCL1 (0.43) | MCL1MARK3NEK4PRKCDCAMK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109715632-B | Macrocyclic indole derivatives | 拜尔公开股份有限公司 | 2021-10-26 | — | — | CN | disclosed |