Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 15/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.48 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22532368 | 0.92 | FGFR4 (0.49) | FGFR4FGFR1FGFR2FGFR3MAPT | |
| SCHEMBL16071565 | 0.88 | FGFR4 (0.55) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL16071675 | 0.88 | FGFR4 (0.60) | FGFR4FGFR1FGFR2FGFR3MAPT | |
| SCHEMBL28656646 | 0.84 | FGFR4 (0.50) | FGFR4FGFR1FGFR2FGFR3MAPT | |
| SCHEMBL22532554 | 0.84 | FGFR4 (0.53) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL29388619 | 0.84 | FGFR4 (0.53) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL28652005 | 0.82 | FGFR4 (0.62) | FGFR4FGFR1FGFR2FGFR3MAPT | |
| SCHEMBL16071480 | 0.81 | FGFR4 (0.48) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL28651460 | 0.78 | FGFR4 (0.63) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL28652250 | 0.78 | FGFR4 (0.62) | FGFR4FGFR1FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113527311-B | FGFR4 inhibitor, composition and application thereof in preparation of medicines | 中南大学湘雅医院 | 2022-05-06 | — | — | CN | disclosed |
| CN-113527311-A | FGFR4 inhibitor, composition and application thereof in preparation of medicines | 中南大学湘雅医院 | 2021-10-22 | — | — | CN | disclosed |