Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 13/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.50 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22532368 | 0.92 | FGFR4 (0.49) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL28637841 | 0.84 | FGFR4 (0.48) | FGFR4FGFR1FGFR2FGFR3MAPT | |
| SCHEMBL28633170 | 0.83 | FGFR4 (0.64) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL22532554 | 0.80 | FGFR4 (0.53) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL29388619 | 0.80 | FGFR4 (0.53) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL16071565 | 0.79 | FGFR4 (0.55) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL20734044 | 0.77 | FGFR1 (0.56) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL16071406 | 0.77 | FGFR4 (0.72) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL20733979 | 0.76 | FGFR4 (0.68) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL28651460 | 0.76 | FGFR4 (0.63) | FGFR4FGFR1FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113527311-B | FGFR4 inhibitor, composition and application thereof in preparation of medicines | 中南大学湘雅医院 | 2022-05-06 | — | — | CN | disclosed |
| CN-113527311-A | FGFR4 inhibitor, composition and application thereof in preparation of medicines | 中南大学湘雅医院 | 2021-10-22 | — | — | CN | disclosed |