Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20349602 | 0.92 | ALDH1A1 (0.48) | ARALDH1A1GAATNFDRD2 | |
| SCHEMBL4838513 | 0.87 | ALDH1A1 (0.48) | ARALDH1A1IMPDH2GAAABL1 | |
| SCHEMBL7605997 | 0.86 | CYP4F2 (0.51) | ARALDH1A1IMPDH2TNFDRD2 | |
| SCHEMBL286438 | 0.82 | ALDH1A1 (0.49) | ARALDH1A1IMPDH2GAAHTT | |
| SCHEMBL2728844 | 0.82 | GAA (0.62) | ARALDH1A1IMPDH2GAATSHR | |
| SCHEMBL908271 | 0.82 | ABL1 (0.59) | ALDH1A1GAADRD2HTTSMN1; SMN2 | |
| SCHEMBL23832225 | 0.82 | MAPT (0.45) | ALDH1A1HTTSMN1; SMN2KDM4EPKM | |
| SCHEMBL5357828 | 0.82 | DAO (0.43) | ALDH1A1SMN1; SMN2KDM4EPKMNFKB1 | |
| SCHEMBL30154437 | 0.82 | MAPT (0.45) | ALDH1A1HTTSMN1; SMN2KDM4EPKM | |
| SCHEMBL13076912 | 0.81 | ALDH1A1 (0.45) | ARALDH1A1IMPDH2GAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2755656-B1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME (US) | 2016-09-07 | — | — | EP | disclosed |
| US-9073882-B2 | Inhibitors of the renal outer medullary potassium channel | MERCK SHARP & DOHME CORP. (US) | 2015-07-07 | — | — | US | disclosed |
| EP-2427444-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2012-03-14 | — | — | EP | disclosed |