Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 3/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | FABP4 | P15090 | 2/20 | 0.48 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.46 |
| ▸ | ACLY | P53396 | 3/20 | 0.46 |
| ▸ | XDH | P47989 | 1/20 | 0.45 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28636849 | 0.82 | PFKFB3 (0.67) | PFKFB3MCL1ALDH1A1HSD17B10HPGD | |
| SCHEMBL9997545 | 0.81 | ACLY (0.57) | PFKFB3MCL1ALDH1A1HSD17B10MEN1 | |
| SCHEMBL28642186 | 0.78 | PFKFB3 (0.56) | PFKFB3MCL1ALDH1A1HSD17B10HPGD | |
| SCHEMBL9996996 | 0.78 | PFKFB3 (0.57) | PFKFB3MCL1ALDH1A1HSD17B10MEN1 | |
| SCHEMBL9996952 | 0.78 | HPGD (0.72) | PFKFB3MCL1ALDH1A1HSD17B10HPGD | |
| SCHEMBL9997432 | 0.78 | PFKFB3 (0.58) | PFKFB3MCL1ALDH1A1HSD17B10HPGD | |
| SCHEMBL9997127 | 0.76 | PFKFB3 (0.66) | PFKFB3MCL1MEN1KMT2AACLY | |
| SCHEMBL15055727 | 0.76 | PFKFB3 (0.50) | PFKFB3MCL1ALDH1A1HSD17B10HPGD | |
| SCHEMBL19281354 | 0.76 | MCL1 (0.64) | PFKFB3MCL1ALDH1A1HSD17B10HPGD | |
| SCHEMBL28646113 | 0.76 | PFKFB3 (0.64) | PFKFB3MCL1ALDH1A1HSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113396145-A | PFKFB3 inhibitors and uses thereof | 盖罗发现有限责任公司 | 2021-09-14 | — | — | CN | disclosed |