Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.54 |
| ▸ | CCR3 | P51677 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2953321 | 1.00 | ACHE (0.54) | ACHECCR3KDM4ESIGMAR1CXCR4 | |
| SCHEMBL18848489 | 1.00 | ACHE (0.54) | ACHECCR3KDM4ESIGMAR1CXCR4 | |
| SCHEMBL5228400 | 0.86 | ACHE (0.60) | ACHECCR3SIGMAR1CXCR4DRD2 | |
| SCHEMBL19450643 | 0.83 | ACHE (0.61) | ACHECCR3KDM4ESIGMAR1CXCR4 | |
| SCHEMBL7651915 | 0.81 | ACHE (0.62) | ACHECCR3KDM4ESIGMAR1CXCR4 | |
| SCHEMBL19770184 | 0.81 | ACHE (0.62) | ACHECCR3KDM4ESIGMAR1CXCR4 | |
| SCHEMBL8265859 | 0.81 | ACHE (0.54) | ACHECCR3SIGMAR1DRD2BCHE | |
| SCHEMBL13389835 | 0.80 | NPC1 (0.54) | DRD2DRD4DRD3 | |
| SCHEMBL2944895 | 0.79 | CHRM2 (0.57) | ACHESIGMAR1DRD4 | |
| SCHEMBL7380899 | 0.79 | BCHE (0.56) | ACHEKDM4ESIGMAR1BCHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3371164-B1 | N-[2-(1-BENZYLPIPERIDIN-4-YL)ETHYL]-4-(PYRAZIN-2-YL)-PIPERAZINE-1-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS MUSCARINIC RECEPTOR 4 (M4) ANTAGONISTS FOR TREATING NEUROLOGICAL DISEASES | NEUROCRINE BIOSCIENCES INC (US) | 2022-03-16 | — | — | EP | disclosed |
| CN-108349936-B | Compounds as muscarinic receptor 4 antagonists | 纽罗克里生物科学有限公司 | 2021-10-01 | — | — | CN | disclosed |