Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CD38 | P28907 | 1/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6269267 | 0.90 | PLK1 (0.53) | PLK1HDAC1RAB9ARPS6KB1CDC7 | |
| SCHEMBL12427631 | 0.88 | PLK1 (0.67) | PLK1HDAC1HDAC8HDAC6HSD17B10 | |
| SCHEMBL6603904 | 0.80 | PLK1 (0.59) | PLK1HDAC1HDAC8HDAC6HSD17B10 | |
| SCHEMBL28639588 | 0.80 | AURKA (0.56) | PLK1NPC1RAB9ATDP1CD38 | |
| SCHEMBL5263528 | 0.80 | PLK1 (0.45) | PLK1NPC1RAB9ACD38MKNK2 | |
| SCHEMBL30311518 | 0.77 | HSD17B10 (0.63) | PLK1HDAC1HDAC8HDAC6HSD17B10 | |
| SCHEMBL2754257 | 0.77 | HSD17B10 (0.63) | PLK1HDAC1HDAC8HDAC6HSD17B10 | |
| SCHEMBL1715550 | 0.77 | PLK1 (0.62) | PLK1HSD17B10JAK2JAK1TYK2 | |
| SCHEMBL4982611 | 0.76 | HSD17B10 (0.59) | HDAC1HDAC8HDAC6HSD17B10NPC1 | |
| SCHEMBL4529804 | 0.76 | BACE1 (0.51) | PLK1HDAC1HDAC8HDAC6HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113563272-B | Preparation method of 2-phenylquinazolinone compound | 三峡大学 | 2023-03-10 | — | — | CN | disclosed |
| CN-113563272-A | Preparation method of 2-phenylquinazolinone compound | 三峡大学 | 2021-10-29 | — | — | CN | disclosed |