Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | FABP4 | P15090 | 4/20 | 0.48 |
| ▸ | FABP5 | Q01469 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9997295 | 0.86 | PFKFB3 (0.60) | PFKFB3ALDH1A1HSD17B10HPGDMEN1 | |
| SCHEMBL28646113 | 0.84 | PFKFB3 (0.64) | PFKFB3ALDH1A1HSD17B10HPGDMEN1 | |
| SCHEMBL28636849 | 0.84 | PFKFB3 (0.67) | PFKFB3ALDH1A1HSD17B10HPGDMEN1 | |
| SCHEMBL28648026 | 0.81 | PFKFB3 (0.63) | PFKFB3ALDH1A1HSD17B10HPGDMEN1 | |
| SCHEMBL9997101 | 0.80 | PFKFB3 (0.65) | PFKFB3ALDH1A1HSD17B10HPGDMEN1 | |
| SCHEMBL28646377 | 0.79 | PFKFB3 (0.59) | PFKFB3ALDH1A1HSD17B10HPGDMEN1 | |
| SCHEMBL9997390 | 0.78 | PFKFB3 (0.65) | PFKFB3ALDH1A1HSD17B10HPGDMEN1 | |
| SCHEMBL28652684 | 0.78 | FABP4 (0.59) | PFKFB3ALDH1A1HSD17B10HPGDMEN1 | |
| SCHEMBL28657437 | 0.78 | PFKFB3 (0.59) | PFKFB3ALDH1A1HSD17B10HPGDMEN1 | |
| SCHEMBL28657642 | 0.78 | HSD17B10 (0.56) | PFKFB3ALDH1A1HSD17B10HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113396145-A | PFKFB3 inhibitors and uses thereof | 盖罗发现有限责任公司 | 2021-09-14 | — | — | CN | disclosed |