Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 13/20 | 0.68 |
| ▸ | LCK | P06239 | 10/20 | 0.68 |
| ▸ | BTK | Q06187 | 7/20 | 0.68 |
| ▸ | EGFR | P00533 | 4/20 | 0.56 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.45 |
| ▸ | JAK1 | P23458 | 3/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31039879 | 1.00 | JAK3 (0.68) | JAK3LCKBTKEGFRJAK2 | |
| SCHEMBL21855193 | 1.00 | JAK3 (0.68) | JAK3LCKBTKEGFRJAK2 | |
| SCHEMBL28653131 | 0.88 | JAK3 (0.63) | JAK3LCKBTKEGFR | |
| SCHEMBL21855199 | 0.88 | JAK3 (0.63) | JAK3LCKBTKEGFR | |
| SCHEMBL31039883 | 0.88 | JAK3 (0.63) | JAK3LCKBTKEGFR | |
| SCHEMBL30011291 | 0.87 | JAK3 (0.76) | JAK3LCKBTKEGFRJAK2 | |
| SCHEMBL28642039 | 0.87 | JAK3 (0.76) | JAK3LCKBTKEGFRJAK2 | |
| SCHEMBL28642037 | 0.87 | JAK3 (0.76) | JAK3LCKBTKEGFRJAK2 | |
| SCHEMBL21946816 | 0.87 | JAK3 (0.69) | JAK3LCKBTKEGFRJAK2 | |
| SCHEMBL21946362 | 0.86 | JAK3 (0.78) | JAK3LCKBTKEGFRJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113412259-A | Bifunctional compounds for the degradation of BTK via the ubiquitin proteasome pathway | 紐力克斯治疗公司 | 2021-09-17 | — | — | CN | disclosed |