⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14157902 | 0.79 | LMNA (0.38) | — | |
| SCHEMBL7111619 | 0.73 | — | — | |
| SCHEMBL12849093 | 0.73 | — | — | |
| SCHEMBL13082857 | 0.73 | — | — | |
| SCHEMBL911186 | 0.73 | — | — | |
| Bromide SCHEMBL27711968 | 0.71 | — | — | |
| Hydrochloric Acid SCHEMBL11123545 | 0.71 | — | — | |
| SCHEMBL937051 | 0.69 | — | — | |
| SCHEMBL24092146 | 0.69 | — | — | |
| SCHEMBL24435669 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113527414-A | Compositions containing non-natural amino acid linked dolastatin derivatives, methods involving the dolastatin derivatives, and uses thereof | AMBRX公司 | 2021-10-22 | — | — | CN | disclosed |
| CN-110078788-B | Dolastatin derivatives containing unnatural amino acid linkages | AMBRX 公司 | 2021-08-06 | — | — | CN | disclosed |