Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Flunixin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 9/20 | 0.95 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.95 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.69 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | GMNN | O75496 | 1/20 | 0.54 |
| ▸ | TTR | P02766 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Flunixin SCHEMBL8325584 | 0.98 | DHODH (1.00) | DHODHHDAC6CYP1A2HIF1ATSHR | |
| Flunixin SCHEMBL29439899 | 0.98 | DHODH (1.00) | DHODHHDAC6CYP1A2HIF1ATSHR | |
| Flunixin SCHEMBL42911 | 0.98 | DHODH (1.00) | DHODHHDAC6CYP1A2HIF1ATSHR | |
| Flunixin SCHEMBL31696761 | 0.98 | DHODH (1.00) | DHODHHDAC6CYP1A2HIF1ATSHR | |
| Flunixin SCHEMBL28754969 | 0.96 | DHODH (0.98) | DHODHHDAC6CYP1A2HIF1ATSHR | |
| Flunixin SCHEMBL4117904 | 0.96 | DHODH (0.98) | DHODHHDAC6CYP1A2HIF1ATSHR | |
| Flunixin SCHEMBL27694863 | 0.93 | DHODH (0.91) | DHODHHDAC6CYP1A2HIF1ATSHR | |
| Flunixin SCHEMBL7164324 | 0.91 | DHODH (0.87) | DHODHHDAC6CYP1A2HIF1ATSHR | |
| Flunixin SCHEMBL29811437 | 0.89 | DHODH (0.84) | DHODHHDAC6CYP1A2HIF1ATSHR | |
| SCHEMBL11485538 | 0.86 | DHODH (0.78) | DHODHHDAC6CYP1A2HIF1ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111479574-B | Compounds for the treatment and prevention of extracellular histone mediated pathologies | 澳大利亚国立大学 | 2024-02-09 | — | — | CN | disclosed |
| CN-117462563-A | Compounds for the treatment and prevention of extracellular histone mediated pathologies | 澳大利亚国立大学 | 2024-01-30 | — | — | CN | disclosed |
| CN-117427084-A | Compounds for the treatment and prevention of extracellular histone mediated pathologies | 澳大利亚国立大学 | 2024-01-23 | — | — | CN | disclosed |
| CN-113473992-A | Compounds for the treatment and prevention of complications associated with neutrophil extracellular traps | 澳大利亚国立大学 | 2021-10-01 | — | — | CN | disclosed |