Flunixin

Flunixin

SCHEMBL42911

Cc1c(Nc2ncccc2C(=O)O)cccc1C(F)(F)F

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 8/20 1.00
HDAC6 Q9UBN7 1/20 1.00
CYP1A2 P05177 2/20 0.71
HIF1A Q16665 2/20 0.71
TSHR P16473 1/20 0.71
TAS2R14 Q9NYV8 2/20 0.68
MEN1 O00255 4/20 0.56
KMT2A Q03164 4/20 0.56
LMNA P02545 3/20 0.56
PKM P14618 2/20 0.56
ALDH1A1 P00352 2/20 0.56
GMNN O75496 1/20 0.56
TTR P02766 1/20 0.56
CYP3A4 P08684 1/20 0.56
CYP2C9 P11712 1/20 0.56
NFKB1 P19838 1/20 0.56
UGT1A1 P22309 1/20 0.56
PTGS1 P23219 1/20 0.56
PTGS2 P35354 1/20 0.56
PMP22 Q01453 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Flunixin SCHEMBL29439899 1.00 DHODH (1.00) DHODHHDAC6CYP1A2HIF1ATSHR
Flunixin SCHEMBL31696761 1.00 DHODH (1.00) DHODHHDAC6CYP1A2HIF1ATSHR
Flunixin SCHEMBL8325584 1.00 DHODH (1.00) DHODHHDAC6CYP1A2HIF1ATSHR
Flunixin SCHEMBL28754969 0.99 DHODH (0.98) DHODHHDAC6CYP1A2HIF1ATSHR
Flunixin SCHEMBL4117904 0.99 DHODH (0.98) DHODHHDAC6CYP1A2HIF1ATSHR
Flunixin SCHEMBL28644103 0.98 DHODH (0.95) DHODHHDAC6CYP1A2HIF1ATSHR
Flunixin SCHEMBL27694863 0.95 DHODH (0.91) DHODHHDAC6CYP1A2HIF1ATSHR
Flunixin SCHEMBL7164324 0.93 DHODH (0.87) DHODHHDAC6CYP1A2HIF1ATSHR
Flunixin SCHEMBL29811437 0.92 DHODH (0.84) DHODHHDAC6CYP1A2HIF1ATSHR
SCHEMBL11485538 0.88 DHODH (0.78) DHODHHDAC6CYP1A2HIF1ATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 7563 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4255391-B1 LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION METRIOPHARM AG (CH) 2026-05-06 EP claimed
US-20260000741-A1 METHOD OF AMELIORATING A PRO-INFLAMMATORY IMMUNOPHENOTYPE IN FARBER DISEASE SUBJECTS BY REPEATED ADMINISTRATION OF A RECOMBINANT HUMAN ACID CERAMIDASE ACERAGEN INC (US) 2026-01-01 US claimed
EP-3699174-B1 COMPOSITION FOR PREVENTING OR TREATING TNF-RELATED DISEASES, CONTAINING DERIVATIVE AS ACTIVE INGREDIENT, AND METHOD FOR INHIBITING TNF ACTIVITY BY USING SAME ILAB (KR) 2025-11-12 EP claimed
CN-115710217-B Flunixin meglumine synthesis method suitable for industrial production 江苏恒盛药业有限公司 2025-06-13 CN claimed
WO-2025122600-A1 COMPOSITIONS AND METHODS FOR TREATING ABERRANT NITROSYLATION CASE WESTERN RESERVE UNIVERSITY (US) 2025-06-12 WO claimed
CN-120114488-A Probiotic composition and application thereof 四川厌氧生物科技有限责任公司 2025-06-10 CN claimed
US-12295811-B2 Ligature device and method of use Chinook Contract Research Inc. (CA) 2025-05-13 US claimed
CN-119735540-A Compounds and compositions for the treatment of diseases associated with STING activity 诺华制药股份有限公司 2025-04-01 CN claimed
EP-4518682-A1 USE OF NON-THERAPEUTIC ANTI-INFLAMMATORY MOLECULES IN PIGS Vetoquinol SA (FR) 2025-03-12 EP claimed
US-20250041208-A1 NEW INJECTABLE COMBINATION FORMULATION NANEXA AB (SE) 2025-02-06 US claimed
EP-0466650-A2 Improvements in non-steroidal anti-inflammatory therapy WARNER-LAMBERT COMPANY (US) 1992-01-15 EP claimed
EP-0280887-B1 MIXED MICELLE SOLUTIONS CONTAINING NON-STEROIDAL ANTI-INFLAMMATORY AGENTS F. HOFFMANN-LA ROCHE AG (CH) 1992-01-08 EP claimed
EP-0408496-A2 Solid dosage form for pharmaceutical substances CIBA-GEIGY AG (CH) 1991-01-16 EP claimed
US-4882164-A CHOLANIC ACID SALTS, LIPIDS, ANTIINFLAMMATORY AGENTS HOFFMANN-LA ROCHE INC. (US) 1989-11-21 US claimed
EP-0130524-B1 DEPOT ANTIPHLOGISTICS Troponwerke GmbH & Co. KG (DE) 1989-08-23 EP claimed
EP-0280887-A1 Mixed micelle solutions containing non-steroidal anti-inflammatory agents F. HOFFMANN-LA ROCHE AG (CH) 1988-09-07 EP claimed
US-4594357-A Depot antiinflammatory agents TROPONWERKE GMBH & CO. (DE) 1986-06-10 US claimed
EP-0152379-A2 Process for preparing pharmaceutical compositions containing unilamellar liposomes CIBA-GEIGY AG (CH) 1985-08-21 EP claimed
EP-0130524-A2 Depot antiphlogistics Troponwerke GmbH & Co. KG (DE) 1985-01-09 EP claimed
EP-0051278-A1 Soft tertiary amine esters of bio-affecting carboxylic acids, processes for preparing and a pharmaceutical composition containing the same MERCK & CO. INC. (US) 1982-05-12 EP claimed