Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Butyrylhydroxamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 5/20 | 0.84 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.84 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.84 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.84 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.84 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.56 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | KDM6B | O15054 | 1/20 | 0.52 |
| ▸ | KDM5C | P41229 | 1/20 | 0.52 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.52 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.52 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.52 |
| ▸ | CTSD | P07339 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butyrylhydroxamic Acid SCHEMBL264922 | 0.92 | — | — | |
| Butyrylhydroxamic Acid SCHEMBL15650014 | 0.89 | — | — | |
| Acetic Acid SCHEMBL11493560 | 0.85 | HSP90AA1 (0.71) | HDAC2HDAC8HDAC3HDAC1HDAC6 | |
| Acetic Acid SCHEMBL9835604 | 0.81 | HSP90AA1 (0.87) | HDAC2HDAC8HDAC3HDAC1HDAC6 | |
| Acetic Acid SCHEMBL9836249 | 0.81 | HSP90AA1 (0.87) | HDAC2HDAC8HDAC3HDAC1HDAC6 | |
| SCHEMBL402760 | 0.76 | — | — | |
| Acetic Acid SCHEMBL28006042 | 0.75 | FOLH1 (0.54) | HDAC2HDAC8HDAC3HDAC1HDAC6 | |
| SCHEMBL742031 | 0.74 | — | — | |
| Hydrochloric Acid SCHEMBL31229280 | 0.74 | — | — | |
| SCHEMBL15598241 | 0.73 | HDAC3 (0.65) | HDAC2HDAC8HDAC3HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113348181-A | DC-SIGN antibody conjugates comprising a STING agonist | 诺华股份有限公司 | 2021-09-03 | — | — | CN | disclosed |