SCHEMBL2864477

SCHEMBL2864477

OC(c1ccccc1)(c1ccccc1)C(O)(c1ccc(Cl)cc1)c1ccc(Cl)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.61
MAPK1 P28482 2/20 0.61
HIF1A Q16665 1/20 0.61
MEN1 O00255 2/20 0.54
KMT2A Q03164 2/20 0.54
BCL2 P10415 1/20 0.50
CYP19A1 P11511 3/20 0.48
KIF11 P52732 1/20 0.48
CYP1A2 P05177 1/20 0.48
L3MBTL1 Q9Y468 3/20 0.47
HTT P42858 3/20 0.46
NPSR1 Q6W5P4 2/20 0.46
LMNA P02545 1/20 0.46
MIF P14174 1/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
XBP1 P17861 1/20 0.45
CES2 O00748 1/20 0.44
CES1 P23141 1/20 0.44
ORAI1 Q96D31 1/20 0.44
ORAI2 Q96SN7 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11511851 1.00 TSHR (0.61) TSHRMAPK1HIF1AMEN1KMT2A
SCHEMBL2860836 0.89 TSHR (0.74) TSHRMAPK1HIF1AMEN1KMT2A
SCHEMBL2391264 0.87 CYP19A1 (0.62) TSHRMAPK1HIF1AMEN1KMT2A
SCHEMBL2389063 0.87 CYP19A1 (0.62) TSHRMAPK1HIF1AMEN1KMT2A
SCHEMBL7173455 0.86 CYP1A2 (0.48) TSHRMAPK1HIF1AMEN1KMT2A
SCHEMBL36629 0.86 CYP1A2 (0.48) TSHRMAPK1HIF1AMEN1KMT2A
SCHEMBL11815667 0.85 TSHR (0.56) TSHRMAPK1HIF1AMEN1KMT2A
SCHEMBL16144309 0.83 KMT2A (0.82) TSHRMAPK1HIF1AMEN1KMT2A
SCHEMBL4062666 0.83 KMT2A (0.82) TSHRMAPK1HIF1AMEN1KMT2A
SCHEMBL9906175 0.83 KMT2A (0.82) TSHRMAPK1HIF1AMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3597441-B1 METHOD OF PRODUCING A MULTILAYERED PRODUCT TRIP LICENSES BV (NL) 2021-04-28 EP disclosed
EP-3449315-B1 RADIATION CURABLE DRY TONER AND METHOD FOR PREPARING THE SAME XEIKON MFG NV (BE) 2021-03-31 EP disclosed
US-10919288-B2 Method of producing a multilayered product PROCRAFT DEVELOPMENT BV (NL) 2021-02-16 US disclosed
EP-3510058-A1 POLYMERIZING COMPOSITION, METHOD OF MANUFACTURE THEREOF AND ARTICLES COMPRISING THE SAME The University of Massachusetts (US) 2019-07-17 EP disclosed
US-20190202953-A1 POLYMERIZING COMPOSITION, METHOD OF MANUFACTURE THEREOF AND ARTICLES COMPRISING THE SAME THE UNIVERSITY OF MASSACHUSETTS 2019-07-04 US disclosed
US-20190129322-A1 Radiation Curable Dry Toner and Method for Preparing the Same XEIKON MANUFACTURING N.V. (BE) 2019-05-02 US disclosed
WO-2018039325-A1 POLYMERIZING COMPOSITION, METHOD OF MANUFACTURE THEREOF AND ARTICLES COMPRISING THE SAME THE UNIVERSITY OF MASSACHUSETTS (US) 2018-03-01 WO disclosed
US-7652128-B2 Toner composition XEROX CORPORATION (US) 2010-01-26 US disclosed
EP-1655323-B1 Toner composition XEROX CORP (US) 2010-01-20 EP disclosed
US-20060100300-A1 Toner composition XEROX CORPORATION 2006-05-11 US disclosed
US-4374963-A Heat curable epoxy-acrylate compositions W. R. GRACE & CO. (US) 1983-02-22 US disclosed
US-4352723-A ULTRAVIOLET RADIATION; PHOTOINITIATOR AND AROMATIC PINACOL W. R. GRACE & CO. (US) 1982-10-05 US disclosed
US-4288527-A Dual UV/thermally curable acrylate compositions with pinacol W. R. GRACE & CO. (US) 1981-09-08 US disclosed
US-4135047-A PREPARATION OF THIOETHERS USING A BENZOPINACOL INITIATOR W. R. GRACE & CO. (US) 1979-01-16 US disclosed
US-4132812-A FREE RADICAL INITIATOR W. R. GRACE & CO. (US) 1979-01-02 US disclosed
US-4117196-A PHOTOCURABLE IMIDIZABLE POLYENE-POLYTHIOL COMPOSITIONS W. R. GRACE & CO. (US) 1978-09-26 US disclosed
US-4117017-A PROCESS FOR PREPARATION OF THIOLS USING A BENZOPINACOL INITIATOR W. R. GRACE & CO. (US) 1978-09-26 US disclosed
US-4106938-A VESICULATING AGENT WHICH LIBERATES GAS ON EXPOSURE TO ACTIVATING RADIATION, THERMOPLASTIC BINDER, DIOL SPEED-INCREASING AGENT EASTMAN KODAK COMPANY (US) 1978-08-15 US disclosed
US-4080484-A POLYAMIDE-ACID OR POLYIMIDE W. R. GRACE & CO. (US) 1978-03-21 US disclosed
US-4020233-A Heat activated ethylenically unsaturated-polythiol compositions W. R. GRACE & CO. (US) 1977-04-26 US disclosed