Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 2/20 | 0.39 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.38 |
| ▸ | SCN4A | P35499 | 2/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18980848 | 0.76 | POLB (0.45) | GAAFUCA1SIGMAR1MEN1KMT2A | |
| SCHEMBL16653600 | 0.76 | POLB (0.45) | GAAFUCA1SIGMAR1MEN1KMT2A | |
| SCHEMBL17061829 | 0.73 | FUCA1 (0.56) | GAAACHEALDH1A1FUCA1SIGMAR1 | |
| SCHEMBL8140451 | 0.73 | FUCA1 (0.56) | GAAACHEALDH1A1FUCA1SIGMAR1 | |
| SCHEMBL23779786 | 0.72 | KMT2A (0.55) | FUCA1MEN1KMT2A | |
| SCHEMBL6482327 | 0.72 | KMT2A (0.55) | FUCA1MEN1KMT2A | |
| SCHEMBL18980315 | 0.72 | KMT2A (0.55) | FUCA1MEN1KMT2A | |
| SCHEMBL20745349 | 0.70 | GAA (0.49) | GAAACHELMNAFUCA1SIGMAR1 | |
| SCHEMBL21178613 | 0.70 | GAA (0.49) | GAAACHELMNAFUCA1SIGMAR1 | |
| SCHEMBL19000134 | 0.70 | ACHE (0.51) | GAAACHELMNAFUCA1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108699032-B | Polycyclic TLR7/8 antagonists and their use in the treatment of immune disorders | 默克专利有限公司 | 2022-07-22 | — | — | CN | disclosed |
| CN-113603675-A | Polycyclic TLR7/8 antagonists and their use in the treatment of immune disorders | 默克专利有限公司 | 2021-11-05 | — | — | CN | disclosed |