SCHEMBL28645658

SCHEMBL28645658

COC(=O)Cn1cc(C(O[SiH](C)C)C(C)(C)C)c(=O)n(C(C)C)c1=O

nearest known ligand 0.34

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.33
KDM4E B2RXH2 1/20 0.32
GAA P10253 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21900235 0.88 KDM4E (0.31) KDM4E
SCHEMBL19873758 0.82
SCHEMBL28652329 0.79 KMT2A (0.37) KDM4EGAA
SCHEMBL28643685 0.72 SMN1; SMN2 (0.40) SMN1; SMN2KDM4EGAA
SCHEMBL28638670 0.71 SMN1; SMN2 (0.39) SMN1; SMN2KDM4EGAA
SCHEMBL28639214 0.71 SMN1; SMN2 (0.39) SMN1; SMN2KDM4EGAA
SCHEMBL3978875 0.70 CYP11B1 (0.38) SMN1; SMN2KDM4EGAA
SCHEMBL28645660 0.69 SMN1; SMN2 (0.34) SMN1; SMN2KDM4EGAA
SCHEMBL480921 0.68 SYK (0.36) KDM4E
SCHEMBL17870741 0.67 GRIA1 (0.35) KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107428744-B Novel heterocyclic compounds and their use in medicine and cosmetics 盖尔德马研究及发展公司 2021-09-24 CN disclosed