Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 5/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 5/20 | 0.35 |
| ▸ | GRIA4 | P48058 | 5/20 | 0.35 |
| ▸ | GRIK5 | Q16478 | 5/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TK1 | P04183 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19873985 | 0.83 | HTT (0.34) | GRIA1GRIA2GRIA4GRIK5KMT2A | |
| SCHEMBL21900235 | 0.78 | KDM4E (0.31) | KDM4EMAPTALDH1A1POLB | |
| SCHEMBL456749 | 0.69 | HPGD (0.57) | TK1 | |
| SCHEMBL31281981 | 0.68 | KMT2A (0.44) | GRIA1GRIA2GRIA4GRIK5KMT2A | |
| SCHEMBL19873735 | 0.67 | ATAD2 (0.38) | KMT2AHTTMAPTALDH1A1LMNA | |
| SCHEMBL136440 | 0.66 | HDAC6 (0.43) | GRIA1GRIA2GRIA4GRIK5KMT2A | |
| SCHEMBL11711890 | 0.66 | KMT2A (0.67) | KMT2ACYP1A2KDM4EHTTMAPT | |
| SCHEMBL692624 | 0.66 | LMNA (0.61) | GRIA1GRIA2GRIA4GRIK5KMT2A | |
| SCHEMBL2153060 | 0.66 | GRIA1 (0.60) | GRIA1GRIA2GRIA4GRIK5KMT2A | |
| SCHEMBL770144 | 0.66 | KMT2A (0.60) | GRIA1GRIA2GRIA4GRIK5KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3708566-A1 | NOVEL HETEROCYCLIC COMPOUNDS AND THE USE THEREOF IN MEDICINE AND IN COSMETICS | Galderma Research & Development (FR) | 2020-09-16 | — | — | EP | disclosed |
| EP-3237403-B1 | NOVEL HETEROCYCLIC COMPOUNDS AND THE USE THEREOF IN MEDICINE AND IN COSMETICS | GALDERMA RES & DEV (FR) | 2020-05-06 | — | — | EP | disclosed |
| EP-3237403-A1 | NOVEL HETEROCYCLIC COMPOUNDS AND THE USE THEREOF IN MEDICINE AND IN COSMETICS | Galderma Research & Development (FR) | 2017-11-01 | — | — | EP | disclosed |
| WO-2016102882-A1 | NOVEL HETEROCYCLIC COMPOUNDS AND THE USE THEREOF IN MEDICINE AND IN COSMETICS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2016-06-30 | — | — | WO | disclosed |