Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.74 |
| ▸ | TYK2 | P29597 | 19/20 | 0.69 |
| ▸ | JAK1 | P23458 | 3/20 | 0.66 |
| ▸ | STAT3 | P40763 | 1/20 | 0.64 |
| ▸ | STAT1 | P42224 | 1/20 | 0.64 |
| ▸ | JAK3 | P52333 | 1/20 | 0.64 |
| ▸ | BMPR2 | Q13873 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31369046 | 0.87 | TYK2 (0.84) | JAK2TYK2JAK1STAT3STAT1 | |
| SCHEMBL22647268 | 0.87 | TYK2 (0.84) | JAK2TYK2JAK1STAT3STAT1 | |
| SCHEMBL30968156 | 0.86 | TYK2 (0.82) | JAK2TYK2JAK1STAT3STAT1 | |
| SCHEMBL23779238 | 0.86 | TYK2 (0.82) | JAK2TYK2JAK1STAT3STAT1 | |
| Envucitinib SCHEMBL22647242 | 0.85 | JAK2 (1.00) | JAK2TYK2JAK1STAT3STAT1 | |
| SCHEMBL26045198 | 0.85 | TYK2 (0.71) | JAK2TYK2JAK1STAT3STAT1 | |
| Envucitinib SCHEMBL31369047 | 0.85 | JAK2 (1.00) | JAK2TYK2JAK1STAT3STAT1 | |
| SCHEMBL28642798 | 0.85 | JAK2 (0.57) | JAK2TYK2JAK1 | |
| SCHEMBL22647283 | 0.83 | TYK2 (0.76) | JAK2TYK2JAK1STAT3STAT1 | |
| SCHEMBL28662527 | 0.83 | JAK2 (0.95) | JAK2TYK2JAK1STAT3STAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113563309-B | Pyridine derivative and preparation method and application thereof | 浙江海正药业股份有限公司 | 2024-12-13 | — | — | CN | disclosed |
| CN-113563309-A | Pyridine derivative and preparation method and application thereof | 浙江海正药业股份有限公司 | 2021-10-29 | — | — | CN | disclosed |