Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 7/20 | 0.53 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.53 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.53 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | LYN | P07948 | 3/20 | 0.44 |
| ▸ | SRC | P12931 | 3/20 | 0.44 |
| ▸ | BTK | Q06187 | 3/20 | 0.44 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.41 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.38 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4713056 | 0.84 | FGFR4 (0.51) | FGFR1FGFR4FGFR2FGFR3KDR | |
| SCHEMBL4710907 | 0.82 | FGFR1 (0.49) | FGFR1FGFR4FGFR2FGFR3KDR | |
| SCHEMBL16894021 | 0.81 | BTK (0.54) | FGFR1FGFR4FGFR2FGFR3KDR | |
| SCHEMBL7102082 | 0.80 | FGFR1 (0.47) | FGFR1FGFR4FGFR2FGFR3KDR | |
| SCHEMBL16668633 | 0.80 | FGFR4 (0.56) | FGFR1FGFR4FGFR2FGFR3KDR | |
| SCHEMBL4713077 | 0.79 | FGFR1 (0.56) | FGFR1FGFR4FGFR2FGFR3KDR | |
| SCHEMBL4712669 | 0.79 | FGFR1 (0.58) | FGFR1FGFR4FGFR2FGFR3KDR | |
| SCHEMBL4713251 | 0.79 | FGFR1 (0.55) | FGFR1FGFR4FGFR2FGFR3KDR | |
| Hydrochloric Acid SCHEMBL6325019 | 0.78 | FGFR1 (0.45) | FGFR1FGFR4FGFR2FGFR3KDR | |
| SCHEMBL4710919 | 0.78 | FGFR1 (0.73) | FGFR1FGFR4FGFR2FGFR3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108864081-B | FGFR4 inhibitor and preparation and application thereof | 南京圣和药业股份有限公司 | 2021-11-23 | — | — | CN | disclosed |