Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 6/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 6/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | LYN | P07948 | 3/20 | 0.43 |
| ▸ | SRC | P12931 | 3/20 | 0.43 |
| ▸ | BTK | Q06187 | 3/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.37 |
| ▸ | PAK2 | Q13177 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CCND2 | P30279 | 1/20 | 0.36 |
| ▸ | CCND3 | P30281 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1555734 | 0.84 | BTK (0.50) | FGFR1LYNSRCBTKRIPK2 | |
| SCHEMBL28648564 | 0.80 | FGFR1 (0.53) | FGFR1FGFR4FGFR2FGFR3KDR | |
| SCHEMBL4713056 | 0.78 | FGFR4 (0.51) | FGFR1FGFR4FGFR2FGFR3KDR | |
| SCHEMBL4331732 | 0.77 | FGFR1 (0.40) | FGFR1FGFR4FGFR2FGFR3KDR | |
| SCHEMBL4710907 | 0.77 | FGFR1 (0.49) | FGFR1FGFR4FGFR2FGFR3KDR | |
| SCHEMBL4713077 | 0.76 | FGFR1 (0.56) | FGFR1FGFR4FGFR2FGFR3KDR | |
| SCHEMBL4713251 | 0.76 | FGFR1 (0.55) | FGFR1FGFR4FGFR2FGFR3KDR | |
| SCHEMBL4710919 | 0.75 | FGFR1 (0.73) | FGFR1FGFR4FGFR2FGFR3KDR | |
| SCHEMBL19499673 | 0.75 | FGFR1 (0.45) | FGFR1FGFR4FGFR2FGFR3LYN | |
| Hydrochloric Acid SCHEMBL4712628 | 0.74 | FGFR1 (0.72) | FGFR1FGFR4FGFR2FGFR3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307451-A2 | PROCESS FOR PREPARING 2-(4-PYRIDYL)AMINO-6-DIALKYLOXYPHENYL-PYRIDO 2,3-D]PYRIMIDIN-7-ONES | WARNER-LAMBERT COMPANY LLC (US) | 2003-05-07 | — | — | EP | disclosed |
| WO-2002012237-A2 | PROCESS FOR PREPARING 2-(4-PYRIDYL)AMINO-6-DIALKYLOXYPHENYL-PYRIDO[2,3-D]PYRIMIDIN-7-ONES | WARNER-LAMBERT COMPANY (US) | 2002-02-14 | — | — | WO | disclosed |