Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | VEGFA | P15692 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CCNK | O75909 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31298325 | 0.86 | MEN1 (0.44) | MEN1KMT2AATMVEGFAEGLN1 | |
| SCHEMBL28668419 | 0.86 | MEN1 (0.44) | MEN1KMT2AATMVEGFAEGLN1 | |
| SCHEMBL30520640 | 0.83 | MEN1 (0.50) | MEN1KMT2AATMVEGFAEGLN1 | |
| SCHEMBL1997213 | 0.82 | MEN1 (0.49) | MEN1KMT2AATMVEGFAEGLN1 | |
| SCHEMBL30584532 | 0.82 | MEN1 (0.49) | MEN1KMT2AATMVEGFAEGLN1 | |
| SCHEMBL114519 | 0.82 | VEGFA (0.50) | MEN1KMT2AATMVEGFAEGLN1 | |
| SCHEMBL30042412 | 0.82 | MEN1 (0.49) | MEN1KMT2AATMVEGFAEGLN1 | |
| SCHEMBL12557699 | 0.82 | KMT2A (0.69) | MEN1KMT2AATMVEGFAEGLN1 | |
| SCHEMBL2933302 | 0.82 | MEN1 (0.49) | MEN1KMT2AATMVEGFAEGLN1 | |
| SCHEMBL20577088 | 0.82 | VEGFA (0.52) | MEN1KMT2AVEGFAEGLN1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113683611-A | RET inhibitors, pharmaceutical compositions thereof and uses thereof | 广东东阳光药业有限公司 | 2021-11-23 | — | — | CN | disclosed |