Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 3/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | FLT4 | P35916 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.32 |
| ▸ | TEK | Q02763 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.30 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29023457 | 0.83 | DGAT1 (0.44) | DGAT1EGFRIGF1RSRCFLT4 | |
| SCHEMBL16835903 | 0.78 | DGAT1 (0.39) | DGAT1 | |
| SCHEMBL16610769 | 0.78 | DGAT1 (0.39) | DGAT1EGFRIGF1RSRCFLT4 | |
| SCHEMBL25697650 | 0.78 | DGAT1 (0.41) | DGAT1EGFRIGF1RSRCFLT4 | |
| SCHEMBL17222119 | 0.77 | KLKB1 (0.47) | DGAT1EGFRIGF1RSRCFLT4 | |
| SCHEMBL25225935 | 0.76 | DGAT1 (0.46) | DGAT1EGFRIGF1RSRCFLT4 | |
| SCHEMBL17231922 | 0.75 | KLKB1 (0.37) | DGAT1EGFRIGF1RSRCFLT4 | |
| SCHEMBL16610953 | 0.74 | DGAT1 (0.37) | DGAT1KLKB1NPC1 | |
| SCHEMBL16610950 | 0.74 | DGAT1 (0.37) | DGAT1KLKB1NPC1 | |
| SCHEMBL16679708 | 0.74 | DGAT1 (0.43) | DGAT1EGFRIGF1RSRCFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113620956-B | Transforming growth factor receptor antagonist, preparation method and application thereof | 赛诺哈勃药业（成都）有限公司 | 2023-06-13 | — | — | CN | disclosed |
| CN-113620956-A | Transforming growth factor receptor antagonist, preparation method and application thereof | 成都倍特药业股份有限公司 | 2021-11-09 | — | — | CN | disclosed |