Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 2/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.52 |
| ▸ | PLK4 | O00444 | 2/20 | 0.49 |
| ▸ | PLK1 | P53350 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 4/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.45 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.45 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28074783 | 0.87 | AURKA (0.58) | RAF1AURKAPDPK1PLK4PLK1 | |
| SCHEMBL21680920 | 0.86 | MEN1 (0.61) | RAF1PDPK1PLK4PLK1MEN1 | |
| SCHEMBL249353 | 0.82 | PLK4 (0.55) | RAF1PLK4PLK1MEN1KMT2A | |
| SCHEMBL2945563 | 0.82 | PLK4 (0.55) | RAF1PLK4PLK1MEN1KMT2A | |
| SCHEMBL14658650 | 0.81 | TLK2 (0.60) | PDPK1PLK4PLK1PIM1PIM3 | |
| SCHEMBL14658651 | 0.81 | TLK2 (0.60) | PDPK1PLK4PLK1PIM1PIM3 | |
| SCHEMBL14521087 | 0.81 | PDPK1 (0.55) | RAF1AURKAPDPK1PIM1PSEN1 | |
| SCHEMBL14521055 | 0.80 | CSNK1D (0.54) | RAF1AURKAPDPK1KDRTDP1 | |
| SCHEMBL14521076 | 0.78 | AURKA (0.53) | RAF1AURKAPDPK1PLK4PLK1 | |
| SCHEMBL8220285 | 0.77 | LRRK2 (0.58) | PLK4PLK1PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107935909-B | Synthesis method of nintedanib and intermediate thereof | 上海科胜药物研发有限公司 | 2023-03-17 | — | — | CN | disclosed |
| CN-109803954-B | Preparation method of nintedanib and intermediate thereof | 浙江华海药业股份有限公司 | 2021-12-07 | — | — | CN | disclosed |