Histidine

Histidine

SCHEMBL28655326

NC(CS)C(=O)O.NC(Cc1c[nH]cn1)C(=O)O.[Cu]

nearest known ligand 0.47

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 2/20 0.47
SLC7A11 Q9UPY5 1/20 0.47
SLC7A5 Q01650 3/20 0.41
CYP3A4 P08684 2/20 0.41
CYP1A2 P05177 1/20 0.40
PKM P14618 2/20 0.37
ALPI P09923 1/20 0.37
XIAP P98170 1/20 0.37
GRIA2 P42262 4/20 0.35
GRIA1 P42261 3/20 0.35
GRIA3 P42263 3/20 0.35
GRIA4 P48058 3/20 0.35
HSD17B10 Q99714 2/20 0.35
KDM4E B2RXH2 2/20 0.35
MEN1 O00255 2/20 0.35
LMNA P02545 2/20 0.35
MAPT P10636 2/20 0.35
BLM P54132 2/20 0.35
PMP22 Q01453 2/20 0.35
KMT2A Q03164 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Histidine SCHEMBL27769589 0.98 PTGS1 (0.48) PTGS1SLC7A11SLC7A5CYP3A4CYP1A2
Histidine SCHEMBL18047802 0.98 PTGS1 (0.48) PTGS1SLC7A11SLC7A5CYP3A4CYP1A2
Histidine SCHEMBL4452747 0.98 PTGS1 (0.48) PTGS1SLC7A11SLC7A5CYP3A4CYP1A2
Histidine SCHEMBL851432 0.98 PTGS1 (0.48) PTGS1SLC7A11SLC7A5CYP3A4CYP1A2
Histidine SCHEMBL1673287 0.98 PTGS1 (0.48) PTGS1SLC7A11SLC7A5CYP3A4CYP1A2
Histidine SCHEMBL22091426 0.98 PTGS1 (0.48) PTGS1SLC7A11SLC7A5CYP3A4CYP1A2
Histidine SCHEMBL28511880 0.97 PTGS1 (0.47) PTGS1SLC7A11SLC7A5CYP3A4CYP1A2
Histidine SCHEMBL28203991 0.97 PTGS1 (0.47) PTGS1SLC7A11SLC7A5CYP3A4CYP1A2
Histidine SCHEMBL1692193 0.97 PTGS1 (0.47) PTGS1SLC7A11SLC7A5CYP3A4CYP1A2
Histidine SCHEMBL1257407 0.93 PTGS1 (0.43) PTGS1SLC7A11SLC7A5CYP3A4CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113713860-B Catalytic luminescent copper cluster nanoenzyme and preparation method and application thereof 东南大学 2023-02-28 CN disclosed
CN-113713860-A Catalytic luminescent copper cluster nanoenzyme and preparation method and application thereof 东南大学 2021-11-30 CN disclosed