Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 1/20 | 0.58 |
| ▸ | HTRA1 | Q92743 | 5/20 | 0.55 |
| ▸ | ACE | P12821 | 5/20 | 0.50 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.49 |
| ▸ | ECE1 | P42892 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | FDFT1 | P37268 | 2/20 | 0.48 |
| ▸ | PYGL | P06737 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28656150 | 1.00 | FPR2 (0.58) | FPR2HTRA1ACEGPR34ECE1 | |
| SCHEMBL21960145 | 0.96 | HTRA1 (0.59) | FPR2HTRA1ACEGPR34ECE1 | |
| SCHEMBL18228919 | 0.96 | HTRA1 (0.59) | FPR2HTRA1ACEGPR34ECE1 | |
| SCHEMBL18228819 | 0.95 | FPR2 (0.64) | FPR2HTRA1ACEECE1MEN1 | |
| SCHEMBL21959742 | 0.95 | FPR2 (0.64) | FPR2HTRA1ACEECE1MEN1 | |
| SCHEMBL18228720 | 0.88 | HTRA1 (0.62) | FPR2HTRA1ACEKMT2A | |
| SCHEMBL21959738 | 0.88 | HTRA1 (0.62) | FPR2HTRA1ACEKMT2A | |
| SCHEMBL18228821 | 0.85 | HTRA1 (0.62) | FPR2HTRA1MEN1KMT2AFDFT1 | |
| SCHEMBL21959743 | 0.85 | HTRA1 (0.62) | FPR2HTRA1MEN1KMT2AFDFT1 | |
| SCHEMBL18236106 | 0.85 | HTRA1 (0.62) | FPR2HTRA1ACEGPR34SHMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107531653-B | Novel difluoroketoamide derivatives | 豪夫迈·罗氏有限公司 | 2021-10-19 | — | — | CN | disclosed |