Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | KRAS | P01116 | 10/20 | 0.34 |
| ▸ | AXL | P30530 | 2/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | TIPARP | Q7Z3E1 | 5/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | PARP12 | Q9H0J9 | 1/20 | 0.30 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.30 |
| ▸ | SOS1 | Q07889 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26129936 | 0.89 | GRIA1 (0.34) | KRASAKR1B1TIPARPCYP2C9CYP2C19 | |
| SCHEMBL26108338 | 0.89 | GRIA1 (0.34) | KRASAKR1B1TIPARPCYP2C9CYP2C19 | |
| SCHEMBL28664244 | 0.87 | KRAS (0.37) | DPP4KRASAXLTIPARP | |
| SCHEMBL23496870 | 0.87 | KRAS (0.35) | DPP4KRASAXLAKR1B1TIPARP | |
| SCHEMBL23496692 | 0.87 | KRAS (0.35) | DPP4KRASAXLAKR1B1TIPARP | |
| SCHEMBL24558178 | 0.84 | USP30 (0.39) | DPP4KRAS | |
| SCHEMBL28658815 | 0.82 | KRAS (0.41) | DPP4KRAS | |
| SCHEMBL26686750 | 0.81 | DPP4 (0.36) | DPP4KRASTIPARPPARP1CYP2C9 | |
| SCHEMBL23496779 | 0.80 | KRAS (0.41) | DPP4KRAS | |
| SCHEMBL28654658 | 0.80 | KRAS (0.40) | DPP4KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113508118-A | Fused tricyclic compounds useful as anticancer agents | 阿斯利康(瑞典)有限公司 | 2021-10-15 | — | — | CN | disclosed |