Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 7/20 | 0.37 |
| ▸ | AXL | P30530 | 2/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28656529 | 0.87 | DPP4 (0.37) | KRASAXLDPP4TIPARP | |
| SCHEMBL23496870 | 0.86 | KRAS (0.35) | KRASAXLDPP4TIPARP | |
| SCHEMBL23496692 | 0.86 | KRAS (0.35) | KRASAXLDPP4TIPARP | |
| SCHEMBL24558288 | 0.85 | LMNA (0.40) | KRAS | |
| SCHEMBL28676516 | 0.79 | KRAS (0.43) | KRASDPP4 | |
| SCHEMBL26129936 | 0.76 | GRIA1 (0.34) | KRASTIPARP | |
| SCHEMBL26108338 | 0.76 | GRIA1 (0.34) | KRASTIPARP | |
| SCHEMBL28671313 | 0.76 | KRAS (0.37) | KRASDPP4 | |
| SCHEMBL23496849 | 0.76 | KRAS (0.34) | KRASTIPARP | |
| SCHEMBL23496837 | 0.76 | KRAS (0.34) | KRASTIPARP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113508118-A | Fused tricyclic compounds useful as anticancer agents | 阿斯利康(瑞典)有限公司 | 2021-10-15 | — | — | CN | disclosed |