SCHEMBL28657274

SCHEMBL28657274

BrN1CCNCC1c1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 2/20 0.44
SLC6A4 P31645 2/20 0.44
SLC6A3 Q01959 2/20 0.44
CYP2D6 P10635 1/20 0.44
TAAR1 Q96RJ0 2/20 0.42
HTR2A P28223 1/20 0.41
HTR2C P28335 1/20 0.41
HTR2B P41595 1/20 0.41
HPGD P15428 1/20 0.40
KMT2A Q03164 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
SLC18A3 Q16572 2/20 0.39
SIGMAR1 Q99720 2/20 0.38
HTR3E A5X5Y0 1/20 0.38
HTR3B O95264 1/20 0.38
ADRB1 P08588 1/20 0.38
HTR3A P46098 1/20 0.38
HTR3D Q70Z44 1/20 0.38
HTR3C Q8WXA8 1/20 0.38
CHRNB2 P17787 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7935000 0.80 SLC6A2 (0.43) SLC6A2SLC6A4SLC6A3CYP2D6TAAR1
SCHEMBL4179473 0.78 SLC6A2 (0.44) SLC6A2SLC6A4SLC6A3CYP2D6TAAR1
SCHEMBL2973133 0.78 SLC6A2 (0.44) SLC6A2SLC6A4SLC6A3CYP2D6TAAR1
SCHEMBL470846 0.78 CHRNB2 (0.55) SLC6A2SLC6A4SLC6A3CYP2D6TAAR1
SCHEMBL18914199 0.78 SLC6A2 (0.44) SLC6A2SLC6A4SLC6A3CYP2D6TAAR1
SCHEMBL25053362 0.78 SLC6A2 (0.44) SLC6A2SLC6A4SLC6A3CYP2D6TAAR1
SCHEMBL1579434 0.78 CHRNB2 (0.55) SLC6A2SLC6A4SLC6A3CYP2D6TAAR1
SCHEMBL3976295 0.78 CHRNB2 (0.55) SLC6A2SLC6A4SLC6A3CYP2D6TAAR1
SCHEMBL18913839 0.78 CHRNB2 (0.55) SLC6A2SLC6A4SLC6A3CYP2D6TAAR1
SCHEMBL27600521 0.78 SLC6A2 (0.44) SLC6A2SLC6A4SLC6A3CYP2D6TAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113549046-A Bisbecklonin S derivative and preparation method and application thereof 山东大学 2021-10-26 CN disclosed