Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 14/20 | 0.65 |
| ▸ | EGLN3 | Q9H6Z9 | 6/20 | 0.65 |
| ▸ | VEGFA | P15692 | 5/20 | 0.65 |
| ▸ | FLT1 | P17948 | 5/20 | 0.65 |
| ▸ | TET3 | O43151 | 1/20 | 0.65 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.65 |
| ▸ | ASPH | Q12797 | 1/20 | 0.65 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.65 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.65 |
| ▸ | OGFOD1 | Q8N543 | 1/20 | 0.65 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.65 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.65 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30346108 | 0.92 | EGLN1 (0.63) | EGLN1EGLN3VEGFAFLT1TET3 | |
| SCHEMBL3031409 | 0.92 | EGLN1 (0.63) | EGLN1EGLN3VEGFAFLT1TET3 | |
| Acetic Acid SCHEMBL23501731 | 0.90 | EGLN1 (0.61) | EGLN1EGLN3VEGFAFLT1TET3 | |
| Acetic Acid Methyl Ester SCHEMBL30471482 | 0.84 | EGLN1 (0.64) | EGLN1EGLN3VEGFAFLT1TET3 | |
| SCHEMBL4370919 | 0.83 | EGLN1 (0.68) | EGLN1EGLN3VEGFAFLT1TET3 | |
| SCHEMBL30514566 | 0.83 | EGLN1 (0.68) | EGLN1EGLN3VEGFAFLT1TET3 | |
| Vadadustat SCHEMBL29405970 | 0.79 | EGLN1 (1.00) | EGLN1EGLN3VEGFAFLT1TET3 | |
| Vadadustat SCHEMBL29357486 | 0.79 | EGLN1 (1.00) | EGLN1EGLN3VEGFAFLT1TET3 | |
| SCHEMBL1921394 | 0.79 | EGLN1 (0.64) | EGLN1EGLN3VEGFAFLT1TET3 | |
| Vadadustat SCHEMBL1920738 | 0.79 | EGLN1 (1.00) | EGLN1EGLN3VEGFAFLT1TET3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109593084-B | Prolyl hydroxylase small-molecule photosensitive prodrug and preparation method and application thereof | 中国药科大学 | 2021-09-28 | — | — | CN | disclosed |