Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | PGK1 | P00558 | 4/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | FOS | P01100 | 1/20 | 0.33 |
| ▸ | JUN | P05412 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1521623 | 0.88 | HTT (0.55) | HTTALDH1A1PGK1SYKMAPT | |
| SCHEMBL6207973 | 0.84 | HTT (0.41) | HTTALDH1A1AURKASYKMAPT | |
| SCHEMBL27752949 | 0.81 | HTT (0.41) | HTTALDH1A1PGK1SYKMAPT | |
| SCHEMBL12639128 | 0.79 | ALDH1A1 (0.43) | HTTALDH1A1PGK1SYKMAPT | |
| SCHEMBL6944320 | 0.76 | KMT2A (0.45) | HTTMEN1KMT2ACYP1A2CYP2C19 | |
| SCHEMBL22860573 | 0.76 | HTT (0.56) | HTTALDH1A1AURKAMAPTKDM4E | |
| SCHEMBL16120488 | 0.76 | HTT (0.53) | HTTALDH1A1SYKMAPTSMN1; SMN2 | |
| SCHEMBL12639161 | 0.75 | ALDH1A1 (0.50) | HTTALDH1A1SYKMAPTSMN1; SMN2 | |
| SCHEMBL7508804 | 0.74 | ALDH1A1 (0.40) | ALDH1A1 | |
| SCHEMBL12639125 | 0.74 | ALDH1A1 (0.39) | HTTALDH1A1PGK1SYKMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108864081-B | FGFR4 inhibitor and preparation and application thereof | 南京圣和药业股份有限公司 | 2021-11-23 | — | — | CN | disclosed |