Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Minocycline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 8/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.71 |
| ▸ | MAPT | P10636 | 6/20 | 0.71 |
| ▸ | USP2 | O75604 | 5/20 | 0.71 |
| ▸ | HPGD | P15428 | 2/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | RECQL | P46063 | 1/20 | 0.71 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.69 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.69 |
| ▸ | GRK6 | P43250 | 1/20 | 0.69 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.69 |
| ▸ | ALB | P02768 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | BLM | P54132 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.60 |
| ▸ | THPO | P40225 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Minocycline SCHEMBL2539 | 1.00 | TDP1 (0.71) | TDP1KDM4EMAPTUSP2HPGD | |
| Minocycline SCHEMBL29946502 | 1.00 | TDP1 (0.71) | TDP1KDM4EMAPTUSP2HPGD | |
| Minocycline SCHEMBL1446032 | 1.00 | TDP1 (0.71) | TDP1KDM4EMAPTUSP2HPGD | |
| Minocycline SCHEMBL19063414 | 1.00 | TDP1 (0.71) | TDP1KDM4EMAPTUSP2HPGD | |
| Minocycline SCHEMBL4810001 | 1.00 | TDP1 (0.71) | TDP1KDM4EMAPTUSP2HPGD | |
| Minocycline SCHEMBL2120833 | 1.00 | TDP1 (0.71) | TDP1KDM4EMAPTUSP2HPGD | |
| Minocycline SCHEMBL2537 | 1.00 | TDP1 (0.71) | TDP1KDM4EMAPTUSP2HPGD | |
| Minocycline SCHEMBL6550323 | 1.00 | TDP1 (0.71) | TDP1KDM4EMAPTUSP2HPGD | |
| Minocycline SCHEMBL10477623 | 0.99 | TDP1 (0.70) | TDP1KDM4EMAPTUSP2HPGD | |
| Minocycline SCHEMBL11688992 | 0.99 | TDP1 (0.70) | TDP1KDM4EMAPTUSP2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1489988-B1 | DISPENSING APPARATUS AND CARTRIDGE | ORAPHARMA INC (US) | 2019-09-11 | — | — | EP | disclosed |
| US-9566141-B2 | Medicinal implant device and cartridge | ORAPHARMA, INC. (US) | 2017-02-14 | — | — | US | disclosed |
| US-8480615-B2 | Device for delivering medicinal implants | ORAPHARMA, INC. (US) | 2013-07-09 | — | — | US | disclosed |
| EP-2263596-B1 | Dispensing apparatus and cartridge | ORAPHARMA INC (US) | 2013-06-05 | — | — | EP | disclosed |
| EP-2263596-A1 | Dispensing apparatus and cartridge | Orapharma, Inc. (US) | 2010-12-22 | — | — | EP | disclosed |
| WO-2010065317-A1 | MEDICINAL IMPLANT DEVICE AND CARTRIDGE | ORAPHARMA, INC. (US) | 2010-06-10 | — | — | WO | disclosed |
| US-20100136502-A1 | MEDICINAL IMPLANT DEVICE AND CARTRIDGE | SOLTA MEDICAL, INC. | 2010-06-03 | — | — | US | disclosed |
| US-7699609-B2 | Dispensing apparatus and cartridge with deformable tip | ORAPHARMA, INC. (US) | 2010-04-20 | — | — | US | disclosed |
| WO-2009073704-A1 | MEDICINAL IMPLANT CARTRIDGE | ORAPHARMA, INC. (US) | 2009-06-11 | — | — | WO | disclosed |
| WO-2009073700-A1 | DEVICE FOR DELIVERING MEDICINAL IMPLANTS | ORAPHARMA, INC. (US) | 2009-06-11 | — | — | WO | disclosed |
| WO-2009073707-A1 | ACTUATORS FOR DEVICES DELIVERING MEDICINAL IMPLANTS | ORAPHARMA, INC. (US) | 2009-06-11 | — | — | WO | disclosed |
| US-20090148500-A1 | MEDICINAL IMPLANT CARTRIDGE | BAUSCH HEALTH US, LLC | 2009-06-11 | — | — | US | disclosed |
| US-20090142727-A1 | DEVICE FOR DELIVERING MEDICINAL IMPLANTS | BAUSCH HEALTH AMERICAS, INC. | 2009-06-04 | — | — | US | disclosed |
| US-20090142728-A1 | ACTUATORS FOR DEVICE FOR DELIVERING MEDICINAL IMPLANTS | MEDICIS PHARMACEUTICAL CORPORATION | 2009-06-04 | — | — | US | disclosed |
| EP-1489988-A4 | DISPENSING APPARATUS AND CARTRIDGE | ORAPHARMA INC (US) | 2008-01-02 | — | — | EP | disclosed |
| EP-1489988-A1 | DISPENSING APPARATUS AND CARTRIDGE | Orapharma, Inc. (US) | 2004-12-29 | — | — | EP | disclosed |
| US-20040152042-A1 | Dispensing apparatus and cartridge with deformable tip | MEDICIS PHARMACEUTICAL CORPORATION | 2004-08-05 | — | — | US | disclosed |
| US-6682348-B2 | Dispensing apparatus and cartridge | ORAPHARMA, INC. | 2004-01-27 | — | — | US | disclosed |
| WO-2003082139-A1 | DISPENSING APPARATUS AND CARTRIDGE | ORAPHARMA, INC. (US) | 2003-10-09 | — | — | WO | disclosed |
| US-20030186191-A1 | Dispensing apparatus and cartridge | ORAPHARMA, INC. | 2003-10-02 | — | — | US | disclosed |