Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Minocycline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 8/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.71 |
| ▸ | MAPT | P10636 | 6/20 | 0.71 |
| ▸ | USP2 | O75604 | 5/20 | 0.71 |
| ▸ | HPGD | P15428 | 2/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | RECQL | P46063 | 1/20 | 0.71 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.69 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.69 |
| ▸ | GRK6 | P43250 | 1/20 | 0.69 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.69 |
| ▸ | ALB | P02768 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | BLM | P54132 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.60 |
| ▸ | THPO | P40225 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Minocycline SCHEMBL2865953 | 1.00 | TDP1 (0.71) | TDP1KDM4EMAPTUSP2HPGD | |
| Minocycline SCHEMBL2539 | 1.00 | TDP1 (0.71) | TDP1KDM4EMAPTUSP2HPGD | |
| Minocycline SCHEMBL29946502 | 1.00 | TDP1 (0.71) | TDP1KDM4EMAPTUSP2HPGD | |
| Minocycline SCHEMBL1446032 | 1.00 | TDP1 (0.71) | TDP1KDM4EMAPTUSP2HPGD | |
| Minocycline SCHEMBL19063414 | 1.00 | TDP1 (0.71) | TDP1KDM4EMAPTUSP2HPGD | |
| Minocycline SCHEMBL2120833 | 1.00 | TDP1 (0.71) | TDP1KDM4EMAPTUSP2HPGD | |
| Minocycline SCHEMBL2537 | 1.00 | TDP1 (0.71) | TDP1KDM4EMAPTUSP2HPGD | |
| Minocycline SCHEMBL6550323 | 1.00 | TDP1 (0.71) | TDP1KDM4EMAPTUSP2HPGD | |
| Minocycline SCHEMBL10477623 | 0.99 | TDP1 (0.70) | TDP1KDM4EMAPTUSP2HPGD | |
| Minocycline SCHEMBL11688992 | 0.99 | TDP1 (0.70) | TDP1KDM4EMAPTUSP2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE40183-E1 | 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines | WYETH HOLDINGS CORPORATION (US) | 2008-03-25 | — | — | US | disclosed |
| US-RE40086-E1 | Method for treating bacterial infection with novel 7-substituted-9-substituted amino 6-demethyl-6-deoxytetracyclines | WYETH HOLDINGS CORPORATION (US) | 2008-02-19 | — | — | US | disclosed |
| EP-0536515-B1 | Novel 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines | AMERICAN CYANAMID CO (US) | 2001-12-19 | — | — | EP | disclosed |
| US-5529990-A | ANTIBIOTICS; USEFUL TO TREAT INFECTIONS CAUSED BY BACTERIAL ORGANISM, INCLUDING THOSE WHICH ARE TETRACYCLINE-RESISTANCE | AMERICAN CYANAMID COMPANY (US) | 1996-06-25 | — | — | US | disclosed |
| US-5494903-A | 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines | AMERICAN CYANAMID COMPANY (US) | 1996-02-27 | — | — | US | disclosed |
| EP-0535346-B1 | 9-amino-7-substituted-6-demethyl-6-deoxytetracyclines | AMERICAN CYANAMID CO (US) | 1995-11-02 | — | — | EP | disclosed |
| US-5401863-A | 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines | AMERICAN CYANAMID COMPANY (US) | 1995-03-28 | — | — | US | disclosed |
| US-5326759-A | Veterinary, active against resistant bacteria | AMERICAN CYANAMID COMPANY (US) | 1994-07-05 | — | — | US | disclosed |
| US-5281628-A | Pharmaceuticals | AMERICAN CYANAMID COMPANY (US) | 1994-01-25 | — | — | US | disclosed |
| EP-0535346-A1 | 9-amino-7-substituted-6-demethyl-6-deoxytetracyclines | AMERICAN CYANAMID COMPANY (US) | 1993-04-07 | — | — | EP | disclosed |