Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.35 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.35 |
| ▸ | ADH1B | P00325 | 1/20 | 0.32 |
| ▸ | ADH1C | P00326 | 1/20 | 0.32 |
| ▸ | ADH1A | P07327 | 1/20 | 0.32 |
| ▸ | ADH4 | P08319 | 1/20 | 0.32 |
| ▸ | ADH7 | P40394 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.31 |
| ▸ | KDM4A | O75164 | 1/20 | 0.31 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.31 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16872425 | 0.97 | LMNA (0.48) | LMNAHIF1AEPAS1ADH1BADH1C | |
| SCHEMBL8858237 | 0.97 | LMNA (0.48) | LMNAHIF1AEPAS1ADH1BADH1C | |
| SCHEMBL11593566 | 0.97 | LMNA (0.48) | LMNAHIF1AEPAS1ADH1BADH1C | |
| SCHEMBL7067432 | 0.97 | LMNA (0.48) | LMNAHIF1AEPAS1ADH1BADH1C | |
| SCHEMBL6905821 | 0.97 | LMNA (0.48) | LMNAHIF1AEPAS1ADH1BADH1C | |
| SCHEMBL9051389 | 0.97 | LMNA (0.48) | LMNAHIF1AEPAS1ADH1BADH1C | |
| SCHEMBL11444896 | 0.97 | LMNA (0.48) | LMNAHIF1AEPAS1ADH1BADH1C | |
| SCHEMBL21219896 | 0.97 | LMNA (0.48) | LMNAHIF1AEPAS1ADH1BADH1C | |
| SCHEMBL971387 | 0.97 | LMNA (0.48) | LMNAHIF1AEPAS1 | |
| SCHEMBL28868791 | 0.91 | LMNA (0.45) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427430-A1 | 5-OXO-ETE RECEPTOR ANTAGONIST COMPOUNDS | The Royal Institution for the Advancement of Learning / McGill University (CA) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010127452-A1 | 5-OXO-ETE RECEPTOR ANTAGONIST COMPOUNDS | THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) | 2010-11-11 | — | — | WO | disclosed |