SCHEMBL28660667

SCHEMBL28660667

FC(F)(F)c1ccc(Oc2[c]ccc(-c3noc(C(F)(F)Cl)n3)c2)cc1Cl

nearest known ligand 0.35

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 15/20 0.35
HDAC1 Q13547 13/20 0.35
CASP3 P42574 1/20 0.35
HDAC5 Q9UQL6 5/20 0.34
MAPT P10636 1/20 0.34
HDAC4 P56524 6/20 0.33
HDAC8 Q9BY41 3/20 0.32
NR1H4 Q96RI1 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28681727 0.85 CASP3 (0.43) HDAC6HDAC1CASP3HDAC5HDAC4
SCHEMBL28654893 0.81 HDAC6 (0.44) HDAC6HDAC1HDAC5HDAC4HDAC8
SCHEMBL28675070 0.80 NPSR1 (0.37) HDAC6HDAC1CASP3HDAC5MAPT
SCHEMBL28678985 0.78 HDAC6 (0.41) HDAC6HDAC1HDAC5HDAC4HDAC8
SCHEMBL28660660 0.78 HDAC6 (0.36) HDAC6HDAC1HDAC5HDAC4HDAC8
SCHEMBL28673450 0.78 HDAC6 (0.46) HDAC6HDAC1HDAC5MAPTHDAC4
SCHEMBL28660671 0.78 HDAC6 (0.35) HDAC6HDAC1CASP3HDAC5MAPT
SCHEMBL28673442 0.77 HDAC6 (0.45) HDAC6HDAC1HDAC5HDAC4HDAC8
SCHEMBL28679004 0.77 HDAC4 (0.48) HDAC6HDAC1HDAC5HDAC4HDAC8
SCHEMBL28671171 0.76 HDAC4 (0.36) HDAC6HDAC1HDAC5HDAC4HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113784958-B Oxadiazole compounds for controlling or preventing phytopathogenic fungi PI工业有限公司 2024-04-30 CN claimed
CN-113784958-A Novel oxadiazole compounds for controlling or preventing phytopathogenic fungi PI工业有限公司 2021-12-10 CN claimed
CN-113784958-B Oxadiazole compounds for controlling or preventing phytopathogenic fungi PI工业有限公司 2024-04-30 CN disclosed
CN-113784958-A Novel oxadiazole compounds for controlling or preventing phytopathogenic fungi PI工业有限公司 2021-12-10 CN disclosed