Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FURIN | P09958 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | NAAA | Q02083 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | CCR8 | P51685 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28661950 | 1.00 | FURIN (0.44) | FURINSLC6A4NAAAHCRTR2CHRNB2 | |
| SCHEMBL23564045 | 0.86 | FURIN (0.42) | FURINSLC6A4NAAACHRNB2CHRNA4 | |
| SCHEMBL2760233 | 0.81 | SLC6A4 (0.46) | FURINSLC6A4NAAAHCRTR2HCRTR1 | |
| SCHEMBL2148620 | 0.81 | FURIN (0.48) | FURINSLC6A4HCRTR2CHRNB2CHRNB4 | |
| SCHEMBL2148619 | 0.81 | FURIN (0.48) | FURINSLC6A4HCRTR2CHRNB2CHRNB4 | |
| Hydrochloric Acid SCHEMBL28666157 | 0.80 | SLC6A4 (0.45) | FURINSLC6A4NAAAHCRTR2HCRTR1 | |
| Hydrochloric Acid SCHEMBL29120065 | 0.80 | SLC6A4 (0.45) | FURINSLC6A4NAAAHCRTR2HCRTR1 | |
| SCHEMBL17687984 | 0.75 | HTR7 (0.38) | SLC6A4HTR2AHTR2CHTR2BSLC6A2 | |
| SCHEMBL19381822 | 0.74 | SLC6A4 (0.47) | SLC6A4HTR1ASLC6A2SLC6A3 | |
| SCHEMBL20069365 | 0.73 | FURIN (0.43) | FURINHCRTR2HCRTR1PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110177786-B | Substituted pyrazolo [1,5-A ] pyridine compounds as RET kinase inhibitors | 阿雷生物药品公司 | 2021-12-14 | — | — | CN | disclosed |