Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19030607 | 0.85 | LGMN (0.43) | IRAK4ALDH1A1KDM4E | |
| SCHEMBL19030336 | 0.83 | IRAK4 (0.53) | IRAK4 | |
| SCHEMBL19029944 | 0.81 | IRAK4 (0.53) | IRAK4 | |
| SCHEMBL19046020 | 0.70 | IRAK4 (0.42) | IRAK4ALDH1A1L3MBTL1GAAMAPT | |
| SCHEMBL19030562 | 0.68 | IRAK4 (0.48) | IRAK4ALDH1A1KDM4E | |
| SCHEMBL19030256 | 0.68 | IRAK4 (0.51) | IRAK4 | |
| SCHEMBL19030789 | 0.68 | HIF1A (0.36) | IRAK4ALDH1A1 | |
| SCHEMBL30090056 | 0.68 | IRAK4 (0.51) | IRAK4 | |
| SCHEMBL19029913 | 0.68 | IRAK4 (0.51) | IRAK4 | |
| SCHEMBL19030433 | 0.67 | MAPT (0.49) | ALDH1A1L3MBTL1KDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108473498-B | Pyrazolo [1,5a ] pyrimidine derivatives as IRAK4 modulators | 豪夫迈·罗氏有限公司 | 2021-11-02 | — | — | CN | disclosed |