Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.41 |
| ▸ | PPARG | P37231 | 4/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | GLS | O94925 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21326182 | 0.76 | CHRM2 (0.43) | MEN1KMT2AEPHX1LMNACHRM3 | |
| SCHEMBL21326189 | 0.76 | MEN1 (0.41) | MEN1KMT2AEPHX1GLSLMNA | |
| SCHEMBL7287152 | 0.74 | HTR2A (0.47) | MEN1KMT2AFOLH1EPHX1CYP3A4 | |
| SCHEMBL7287147 | 0.74 | HTR2A (0.47) | MEN1KMT2AFOLH1EPHX1CYP3A4 | |
| SCHEMBL5053199 | 0.74 | FOLH1 (0.66) | FOLH1PPARGPPARAHTR2AHTR2C | |
| SCHEMBL6716257 | 0.74 | MEN1 (0.58) | MEN1KMT2APPARGPPARASLC6A4 | |
| SCHEMBL28678179 | 0.74 | MEN1 (0.47) | MEN1KMT2AEPHX1LMNA | |
| SCHEMBL11515242 | 0.72 | MEN1 (0.43) | MEN1KMT2APPARGPPARA | |
| SCHEMBL9705177 | 0.71 | MEN1 (0.54) | MEN1KMT2ALMNAADORA3SLC6A3 | |
| SCHEMBL8290867 | 0.70 | MEN1 (0.39) | MEN1KMT2APPARGSLC6A3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641912-B | Bicyclic heteroaryl derivatives | 豪夫迈·罗氏有限公司 | 2021-10-29 | — | — | CN | disclosed |