Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6423777 | 0.89 | POLB (0.52) | POLBALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL154270 | 0.85 | ALDH1A1 (0.48) | POLBHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL7877735 | 0.85 | ALDH1A1 (0.48) | POLBHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL28562689 | 0.85 | POLB (0.46) | POLBHDAC3HDAC1HDAC2HDAC8 | |
| Hydrochloric Acid SCHEMBL11203276 | 0.84 | ALDH1A1 (0.47) | POLBHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL2945207 | 0.84 | ALDH1A1 (0.45) | POLBHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL10962715 | 0.82 | POLB (0.47) | POLBHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL2799777 | 0.82 | TDP1 (0.52) | HDAC3HDAC1HDAC2HDAC8NCOR2 | |
| SCHEMBL8987713 | 0.80 | HDAC3 (0.49) | POLBHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL17508109 | 0.80 | ALDH1A1 (0.47) | POLBHDAC3HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109476663-B | Pyrazolopyridine derivatives for the treatment of cancer | 基因泰克公司 | 2021-11-09 | — | — | CN | disclosed |