Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28664076 | 0.83 | ALDH1A1 (0.49) | LMNAALDH1A1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL28663651 | 0.81 | ALDH1A1 (0.37) | LMNAALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL19030760 | 0.73 | TSHR (0.44) | LMNAALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL19030759 | 0.73 | MAPT (0.37) | LMNAALDH1A1SMN1; SMN2POLBMAPT | |
| SCHEMBL19030567 | 0.73 | ALDH1A1 (0.39) | LMNAALDH1A1NPC1SMN1; SMN2HPGD | |
| SCHEMBL19030238 | 0.68 | AKR1B1 (0.42) | LMNAALDH1A1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL19030430 | 0.65 | AKR1B1 (0.41) | ALDH1A1MAPK1AKR1B1 | |
| SCHEMBL19030448 | 0.65 | AKR1B1 (0.46) | LMNAALDH1A1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL19030214 | 0.65 | CYP1A2 (0.42) | LMNAALDH1A1NPC1RAB9APOLB | |
| SCHEMBL19030436 | 0.64 | AKR1B1 (0.39) | LMNAALDH1A1MAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108473498-B | Pyrazolo [1,5a ] pyrimidine derivatives as IRAK4 modulators | 豪夫迈·罗氏有限公司 | 2021-11-02 | — | — | CN | disclosed |