Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 14/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | RARA | P10276 | 1/20 | 0.34 |
| ▸ | RARB | P10826 | 1/20 | 0.34 |
| ▸ | RARG | P13631 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19876271 | 0.83 | BTK (0.57) | BTKLCKKCNH2 | |
| SCHEMBL17670764 | 0.81 | MAPK1 (0.45) | BTKMAPK1GPR52ACVR1MTOR | |
| SCHEMBL17645776 | 0.78 | BTK (0.67) | BTKLCK | |
| SCHEMBL30950500 | 0.78 | BTK (0.67) | BTKLCK | |
| SCHEMBL19876266 | 0.73 | BTK (0.56) | BTKLCKKCNH2 | |
| SCHEMBL19876208 | 0.73 | BTK (0.54) | BTKLCKKCNH2 | |
| SCHEMBL30950434 | 0.71 | BTK (0.56) | BTKLCK | |
| SCHEMBL30950558 | 0.71 | BTK (0.54) | BTKLCK | |
| SCHEMBL19876284 | 0.70 | BTK (0.62) | BTKKCNH2 | |
| SCHEMBL19876240 | 0.70 | BTK (0.47) | BTKLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641892-B | 2-oxo-imidazopyridines as reversible BTK inhibitors and uses thereof | 默克专利有限公司 | 2021-07-02 | — | — | CN | disclosed |