Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 2/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19046170 | 1.00 | PDE4B (0.39) | PDE4BALDH1A1LMNAMAPTPIK3CD | |
| SCHEMBL19030656 | 0.88 | IRAK4 (0.38) | ALDH1A1LMNAIRAK4 | |
| SCHEMBL19030657 | 0.88 | IRAK4 (0.38) | ALDH1A1LMNAIRAK4 | |
| SCHEMBL20595499 | 0.83 | ALDH1A1 (0.36) | PDE4BALDH1A1LMNAMAPTGPR119 | |
| SCHEMBL20595500 | 0.83 | ALDH1A1 (0.36) | PDE4BALDH1A1LMNAMAPTGPR119 | |
| SCHEMBL19030287 | 0.79 | IRAK4 (0.55) | ALDH1A1LMNAIRAK4 | |
| SCHEMBL19030284 | 0.79 | IRAK4 (0.55) | ALDH1A1LMNAIRAK4 | |
| SCHEMBL20594509 | 0.79 | MAPT (0.52) | ALDH1A1LMNAMAPTIRAK4 | |
| SCHEMBL19030546 | 0.77 | IRAK4 (0.46) | MAPTIRAK4 | |
| SCHEMBL28663614 | 0.77 | F2RL3 (0.38) | ALDH1A1LMNAGPR119IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108473498-B | Pyrazolo [1,5a ] pyrimidine derivatives as IRAK4 modulators | 豪夫迈·罗氏有限公司 | 2021-11-02 | — | — | CN | disclosed |