SCHEMBL28669342

SCHEMBL28669342

O=C(O)c1cnc2[nH]c(=O)oc2c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CREBBP Q92793 1/20 0.41
KDM4E B2RXH2 5/20 0.38
ALDH1A1 P00352 5/20 0.38
MGAM O43451 1/20 0.37
PDE3B Q13370 1/20 0.36
PDE3A Q14432 1/20 0.36
P4HA1 P13674 2/20 0.35
P4HTM Q9NXG6 2/20 0.35
MIF P14174 1/20 0.34
HCAR3 P49019 1/20 0.34
SMYD3 Q9H7B4 1/20 0.34
HCAR2 Q8TDS4 4/20 0.33
KDM6B O15054 1/20 0.33
TET3 O43151 1/20 0.33
KDM4A O75164 1/20 0.33
BBOX1 O75936 1/20 0.33
MAPT P10636 1/20 0.33
KDM5A P29375 1/20 0.33
KDM5C P41229 1/20 0.33
ASPH Q12797 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8627144 0.85 CREBBP (0.43) CREBBPKDM4EALDH1A1PDE3BPDE3A
SCHEMBL25272820 0.83 CREBBP (0.58) CREBBPKDM4EALDH1A1PDE3BPDE3A
SCHEMBL24897445 0.80 GRM5 (0.52) KDM4EALDH1A1P4HTM
SCHEMBL24897343 0.74 SMYD3 (0.55) SMYD3EGLN1
SCHEMBL1254504 0.74 RAB9A (0.43) KDM4EALDH1A1P4HTMHCAR2MAPT
SCHEMBL24897452 0.74 PSMB8 (0.53) KDM4EP4HTMKMT2A
SCHEMBL3588183 0.74 PDE3B (0.39) PDE3BPDE3AMAPTLMNA
SCHEMBL488612 0.74 AURKA (0.49) KDM4EALDH1A1PDE3BPDE3AMAPT
Hydrochloric Acid SCHEMBL1253362 0.73 RAB9A (0.43) KDM4EALDH1A1P4HTMHCAR2MAPT
SCHEMBL11916127 0.70 PDE3B (0.39) CREBBPPDE3BPDE3ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4448494-A1 NOVEL SUBSTITUTED FUSED BICYCLIC PYRIDINE CARBOXAMIDE COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI PI Industries Ltd. (IN) 2024-10-23 EP disclosed
WO-2023112056-A1 NOVEL SUBSTITUTED FUSED BICYCLIC PYRIDINE CARBOXAMIDE COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI PI INDUSTRIES LTD. (IN) 2023-06-22 WO disclosed
CN-113557235-A Heterocyclic compounds for use in medical therapy C4医药公司 2021-10-26 CN disclosed