Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1GSK3AGSK3BHRH1HRH2HTR7IDH1IDH2IMPA1IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HMGCR | P04035 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 3/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | CPT2 | P23786 | 1/20 | 0.31 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL5471630 | 0.98 | CA4 (0.76) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL475574 | 0.95 | CA4 (0.73) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL107372 | 0.95 | CA4 (0.73) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL2227453 | 0.95 | CA4 (0.73) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL9004291 | 0.95 | CA4 (0.81) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL104390 | 0.95 | CA4 (0.73) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL9120773 | 0.95 | CA4 (0.73) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL21569387 | 0.95 | CA4 (0.73) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL21569398 | 0.95 | CA4 (0.73) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL18263181 | 0.95 | CA4 (0.73) | CA4ALDH1A1HMGCRCHRM1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2979760-B1 | HYDROGENATION DESULFURIZATION CATALYST FOR DIESEL OIL AND HYDROGENATION TREATMENT METHOD FOR DIESEL OIL | COSMO OIL CO LTD (JP) | 2019-05-01 | — | — | EP | disclosed |
| US-9987622-B2 | Hydrodesulfurization catalyst for diesel oil and hydrotreating method for diesel oil | COSMO OIL CO., LTD. (JP) | 2018-06-05 | — | — | US | disclosed |
| US-20160059223-A1 | HYDRODESULFURIZATION CATALYST FOR DIESEL OIL AND HYDROTREATING METHOD FOR DIESEL OIL | COSMO OIL CO., LTD. (JP) | 2016-03-03 | — | — | US | disclosed |
| EP-2979760-A1 | HYDROGENATION DESULFURIZATION CATALYST FOR DIESEL OIL AND HYDROGENATION TREATMENT METHOD FOR DIESEL OIL | Cosmo Oil Co., Ltd. (JP) | 2016-02-03 | — | — | EP | disclosed |
| EP-1577007-B1 | HYDROTREATING CATALYST FOR GAS OIL, PROCESS FOR PRODUCING THE SAME, AND METHOD OF HYDROTREATING GAS OIL | COSMO OIL CO LTD (JP) | 2013-03-20 | — | — | EP | disclosed |
| EP-1733787-B1 | CATALYST FOR HYDROGENATION TREATMENT OF HYDROCARBON OIL AND METHOD FOR PREPARATION THEREOF, AND METHOD FOR HYDROGENATION TREATMENT OF HYDROCARBON OIL | COSMO OIL CO LTD (JP) | 2013-01-09 | — | — | EP | disclosed |
| EP-1402948-B1 | CATALYST FOR HYDROGENATION TREATMENT OF GAS OIL AND METHOD FOR PREPARATION THEREOF; AND PROCESS FOR HYDROGENATION TREATMENT OF GAS OIL | COSMO OIL CO LTD (JP) | 2013-01-09 | — | — | EP | disclosed |
| CN-1938087-B | Catalyst for hydrogenation treatment of hydrocarbon oil and method for preparation thereof, and method for hydrogenation treatment of hydrocarbon oil | COSMO OIL CO LTD | 2011-02-02 | — | — | CN | disclosed |
| US-7737071-B2 | Catalyst for hydrotreating hydrocarbon oil, process for producing the same, and method for hydrotreating hydrocarbon oil | COSMO OIL CO., LTD. (JP) | 2010-06-15 | — | — | US | disclosed |
| US-7618916-B2 | Hydrotreating catalyst for gas oil, process for producing the same, and method of hydrotreating gas oil | COSMO OIL CO., LTD. (JP) | 2009-11-17 | — | — | US | disclosed |
| CN-1938087-A | Catalyst for hydrogenation treatment of hydrocarbon oil and method for preparation thereof, and method for hydrogenation treatment of hydrocarbon oil | COSMO OIL CO LTD (JP) | 2007-03-28 | — | — | CN | disclosed |
| EP-1733787-A1 | CATALYST FOR HYDROGENATION TREATMENT OF HYDROCARBON OIL AND METHOD FOR PREPARATION THEREOF, AND METHOD FOR HYDROGENATION TREATMENT OF HYDROCARBON OIL | COSMO OIL CO., LTD. (JP) | 2006-12-20 | — | — | EP | disclosed |
| CN-1265879-C | Catalyst for hydrogenation treatmet of gas oil and method for prepn. thereof and process for hydrogenation treatment of gas oil | KOSMO PETROLEUM CO LTD (JP) | 2006-07-26 | — | — | CN | disclosed |
| US-20060116443-A1 | Metal coated carbon black, carbon black compositions and their applications | TIMCAL S.A. (CH) | 2006-06-01 | — | — | US | disclosed |
| US-20060054536-A1 | Hydrotreating catalyst for gas oil, process for producing the same, and method of hydrotreating gas oil | COSMO OIL CO., LTD. (JP) | 2006-03-16 | — | — | US | disclosed |
| CN-1729056-A | Light oil hydrotreating catalyst, preparation method thereof and light oil hydrotreating method | COSMO OIL CO LTD (JP) | 2006-02-01 | — | — | CN | disclosed |
| EP-1577007-A1 | HYDROTREATING CATALYST FOR GAS OIL, PROCESS FOR PRODUCING THE SAME, AND METHOD OF HYDROTREATING GAS OIL | COSMO OIL CO., LTD. (JP) | 2005-09-21 | — | — | EP | disclosed |
| EP-1402948-A1 | CATALYST FOR HYDROGENATION TREATMENT OF GAS OIL AND METHOD FOR PREPARATION THEREOF, AND PROCESS FOR HYDROGENATION TREATMENT OF GAS OIL | COSMO OIL CO., LTD (JP) | 2004-03-31 | — | — | EP | disclosed |
| CN-1463204-A | Catalyst for hydrogenation treatmet of gas oil and method for prepn. thereof and process for hydrogenation treatment of gas oil | KOSMO PETROLEUM CO LTD (JP) | 2003-12-24 | — | — | CN | disclosed |
| US-20030173256-A1 | Catalyst for hydrogenation treatment of gas oil and method for preparation thereof, and process for hydrogenation treatment of gas oil | COSMO OIL CO., LTD. (JP) | 2003-09-18 | — | — | US | disclosed |