Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1GSK3AGSK3BHRH1HRH2HTR7IDH1IDH2IMPA1IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HMGCR | P04035 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 3/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | CPT2 | P23786 | 1/20 | 0.31 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL104389 | 0.98 | CA4 (0.70) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL73056 | 0.98 | CA4 (0.77) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL761595 | 0.98 | CA4 (0.70) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL4889866 | 0.98 | CA4 (0.70) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL2227442 | 0.98 | CA4 (0.70) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL107371 | 0.98 | CA4 (0.70) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL5471630 | 0.98 | CA4 (0.76) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL6864505 | 0.96 | CA4 (0.74) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL1301477 | 0.95 | CA4 (0.73) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL9319655 | 0.95 | CA4 (0.73) | CA4ALDH1A1HMGCRCHRM1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1278 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12503713-B1 | Stabilization of tryptamines by denaturing enzymes, optimizing ionization states, and controlling confounding variables | Convergent Health Sciences LLC (US) | 2025-12-23 | — | — | US | claimed |
| US-12497637-B1 | Stabilization of tryptamines by denaturing enzymes, optimizing ionization states, and controlling confounding variables | Convergent Health Sciences LLC (US) | 2025-12-16 | — | — | US | claimed |
| US-20250312297-A1 | REDUCTION OF HEALTHCARE RESOURCE UTILIZATION BY PATIENTS TREATED WITH INTRANASALLY-ADMINISTERED METOCLOPRAMIDE | EVOKE PHARMA, INC. | 2025-10-09 | — | — | US | claimed |
| US-20250302777-A1 | METHODS FOR TREATING GASTROPARESIS | EVOKE PHARMA, INC. | 2025-10-02 | — | — | US | claimed |
| EP-3853299-B1 | ARYL SCISSION INHIBITION IN ARYL-FUNCTIONALIZED POLYSILOXANE | DOW SILICONES CORP (US) | 2025-08-20 | — | — | EP | claimed |
| CN-116836203-B | Water-soluble Pt (IV) complex with hydroxycarboxylic acid as axial ligand, preparation method and application | 云南贵金属实验室有限公司 | 2025-06-03 | — | — | CN | claimed |
| EP-4447714-B1 | NICOTINE TABLET | FERTIN PHARMA AS (DK) | 2025-05-14 | — | — | EP | claimed |
| US-20250137090-A1 | Compositions and processes for the extraction of metals using non-aqueous solvents | Argo Natural Resources Limited (GB) | 2025-05-01 | — | — | US | claimed |
| CN-119896763-A | Pasty biological tissue adhesive capable of being coated and preparation method and application thereof | 哈尔滨工业大学 | 2025-04-29 | — | — | CN | claimed |
| EP-4508160-A1 | COMPOSITIONS COMPRISING POLYMER, SCALE INHIBITOR AND QUATERNARY AMMONIUM COMPOUND, METHOD AND USES | Independence Oilfield Chemicals, LLC (US) | 2025-02-19 | — | — | EP | claimed |
| US-5681863-A | Non-metabolizable clomiphene analogs for treatment of tamoxifen-resistant tumors | MERRELL PHARMACEUTICALS INC. (US) | 1997-10-28 | — | — | US | claimed |
| US-5653917-A | Rust-removing alkali metal hydrogen citrate composition | SINGERMAN GARY M (US) | 1997-08-05 | — | — | US | claimed |
| US-5256653-A | Pharmaceutical preparations containing platinum complexes/phosphonic acid liquid and processes for their use | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1993-10-26 | — | — | US | claimed |
| US-5034379-A | Antiulcer agents for treatment of lesions from antiinflammatory agents | RAINSFORD KIM D (CA) | 1991-07-23 | — | — | US | claimed |
| EP-0220514-B1 | COMPOSITION FOR INCREASING THE QUANTITY AND QUALITY OF FRUITS AND FLOWERS OF PLANTS | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 1990-05-02 | — | — | EP | claimed |
| EP-0154523-B1 | A PHARMACEUTICAL FORMULATION CONTAINING AZAPROPAZONE | Rainsford, Kim Drummond (GB) | 1989-03-22 | — | — | EP | claimed |
| EP-0131527-B1 | COMPOSITION FOR THE AUTOMATIC CLEANING OF TOILET BOWLS | LESIEUR-COTELLE (FR) | 1986-09-03 | — | — | EP | claimed |
| EP-0154523-A2 | A pharmaceutical formulation containing azapropazone | Rainsford, Kim Drummond (GB) | 1985-09-11 | — | — | EP | claimed |
| US-4295982-A | PRODUCT FROM SULFUR, AMINOGUANIDINE, UNSATURATED ACID; CORROSION RESISTANCE | MOBIL OIL CORPORATION (US) | 1981-10-20 | — | — | US | claimed |
| US-4268694-A | HYDROLYSIS OF TETRAHALOCYCLOHEXANONE | FISONS LIMITED (GB) | 1981-05-19 | — | — | US | claimed |