Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 17/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.50 |
| ▸ | KDR | P35968 | 2/20 | 0.50 |
| ▸ | KIT | P10721 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | AXL | P30530 | 1/20 | 0.50 |
| ▸ | MST1R | Q04912 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28670939 | 1.00 | MET (0.55) | METPDGFRAKDRKITSRC | |
| SCHEMBL28864681 | 0.81 | MET (0.55) | METMST1RCHRM1CHRM5PDK2 | |
| SCHEMBL29870089 | 0.81 | MET (0.55) | METMST1RCHRM1CHRM5PDK2 | |
| SCHEMBL28674546 | 0.80 | MET (0.37) | METPDGFRAKDRPDGFRB | |
| SCHEMBL31037121 | 0.80 | MET (0.37) | METPDGFRAKDRPDGFRB | |
| SCHEMBL28674545 | 0.80 | MET (0.37) | METPDGFRAKDRPDGFRB | |
| SCHEMBL28694465 | 0.78 | MET (0.59) | METPDGFRAKDRKITSRC | |
| SCHEMBL28675971 | 0.78 | MET (0.59) | METPDGFRAKDRKITSRC | |
| SCHEMBL1163741 | 0.76 | MET (0.50) | METPDGFRAKDRPDGFRB | |
| SCHEMBL29870023 | 0.76 | MET (0.50) | METPDGFRAKDRPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113861198-B | Imidazo [4,5-b ] pyrazine compound, preparation method and application thereof | 上海医药集团股份有限公司 | 2024-08-02 | — | — | CN | disclosed |
| CN-113861199-A | Imidazo [4,5-b ] pyrazine compound, preparation method and application thereof | 上海医药集团股份有限公司 | 2021-12-31 | — | — | CN | disclosed |
| CN-113861200-A | Imidazo [4,5-b ] pyrazine compound, preparation method and application thereof | 上海医药集团股份有限公司 | 2021-12-31 | — | — | CN | disclosed |
| CN-113861198-A | Imidazo [4,5-b ] pyrazine compound, preparation method and application thereof | 上海医药集团股份有限公司 | 2021-12-31 | — | — | CN | disclosed |