Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.38 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21179013 | 0.83 | ATM (0.40) | LMNASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL31516455 | 0.80 | KDM4E (0.42) | JAK2MAPTKDM4EALDH1A1RXFP1 | |
| SCHEMBL13167052 | 0.80 | KDM4E (0.42) | JAK2MAPTKDM4EALDH1A1RXFP1 | |
| SCHEMBL3560749 | 0.79 | KDM4E (0.41) | JAK2MAPTKDM4EALDH1A1RXFP1 | |
| SCHEMBL2200166 | 0.77 | NPC1 (0.37) | LMNASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL3565425 | 0.76 | ALDH1A1 (0.44) | JAK2KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL16363333 | 0.76 | KDM4E (0.58) | JAK2LMNASMN1; SMN2RAB9AMAPT | |
| SCHEMBL29073960 | 0.75 | — | — | |
| SCHEMBL29073827 | 0.75 | — | — | |
| SCHEMBL23326620 | 0.74 | BAZ2B (0.40) | JAK2LMNASMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113861203-B | 4-aromatic alkynyl substituted 7H-pyrrolo [2,3-d ] pyrimidine amide compound and preparation method and application thereof | 安徽大学 | 2023-08-08 | — | — | CN | disclosed |
| CN-113861203-A | 4-aromatic alkynyl substituted 7H-pyrrolo [2,3-d ] pyrimidine amide compound and preparation method and application thereof | 安徽大学 | 2021-12-31 | — | — | CN | disclosed |