SCHEMBL28675233

SCHEMBL28675233

Nc1cc(C(=O)O)cc(C(=O)O)c1Cl

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.68
TPMT P51580 1/20 0.46
TTR P02766 1/20 0.43
ALDH1A1 P00352 3/20 0.41
POLB P06746 2/20 0.41
KDM4E B2RXH2 4/20 0.41
KMT2A Q03164 3/20 0.41
HCAR1 Q9BXC0 1/20 0.41
GFER P55789 1/20 0.41
RXFP1 Q9HBX9 1/20 0.41
DAO P14920 1/20 0.41
TDP1 Q9NUW8 3/20 0.40
GPR35 Q9HC97 1/20 0.40
MEN1 O00255 2/20 0.39
USP2 O75604 1/20 0.39
MAPT P10636 1/20 0.39
THRB P10828 1/20 0.39
PKM P14618 1/20 0.39
APEX1 P27695 1/20 0.39
RECQL P46063 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1931732 0.87 TPMT (0.54) CYP3A4TPMTTTRALDH1A1KDM4E
SCHEMBL11257407 0.84 TPMT (0.56) CYP3A4TPMTTTRALDH1A1KDM4E
SCHEMBL31396152 0.81 CYP3A4 (0.70) CYP3A4ALDH1A1POLBKDM4EKMT2A
Chloramben SCHEMBL55091 0.81 CYP3A4 (1.00) CYP3A4TPMTALDH1A1POLBKDM4E
SCHEMBL7190503 0.81 CYP3A4 (0.70) CYP3A4ALDH1A1POLBKDM4EKMT2A
Chloramben SCHEMBL29448826 0.81 CYP3A4 (1.00) CYP3A4TPMTALDH1A1POLBKDM4E
Chloramben SCHEMBL117283 0.81 CYP3A4 (1.00) CYP3A4TPMTALDH1A1POLBKDM4E
SCHEMBL18677631 0.79 CA12 (0.52) CYP3A4TPMTTTRALDH1A1POLB
SCHEMBL10316093 0.79 CYP3A4 (0.68) CYP3A4ALDH1A1POLBKDM4EKMT2A
Chloramben SCHEMBL11629597 0.79 CYP3A4 (0.96) CYP3A4TPMTALDH1A1POLBKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113717067-A Diiodoisophthaloyl chloride compound, preparation method and application thereof 苏州科伦药物研究有限公司 2021-11-30 CN disclosed