Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EBP | Q15125 | 2/20 | 0.61 |
| ▸ | DHCR7 | Q9UBM7 | 2/20 | 0.61 |
| ▸ | S100A4 | P26447 | 5/20 | 0.60 |
| ▸ | PAX8 | Q06710 | 4/20 | 0.60 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 8/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.60 |
| ▸ | THRB | P10828 | 7/20 | 0.60 |
| ▸ | BLM | P54132 | 6/20 | 0.60 |
| ▸ | TOP2A | P11388 | 5/20 | 0.60 |
| ▸ | RECQL | P46063 | 5/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | BRCA1 | P38398 | 4/20 | 0.60 |
| ▸ | HTT | P42858 | 4/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.60 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.60 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17345374 | 1.00 | EBP (0.61) | EBPDHCR7S100A4PAX8HSP90AA1 | |
| SCHEMBL18821853 | 1.00 | EBP (0.61) | EBPDHCR7S100A4PAX8HSP90AA1 | |
| SCHEMBL18787089 | 1.00 | EBP (0.61) | EBPDHCR7S100A4PAX8HSP90AA1 | |
| SCHEMBL28667008 | 1.00 | EBP (0.61) | EBPDHCR7S100A4PAX8HSP90AA1 | |
| SCHEMBL19231138 | 1.00 | EBP (0.61) | EBPDHCR7S100A4PAX8HSP90AA1 | |
| SCHEMBL19565420 | 1.00 | EBP (0.61) | EBPDHCR7S100A4PAX8HSP90AA1 | |
| SCHEMBL18806491 | 1.00 | EBP (0.61) | EBPDHCR7S100A4PAX8HSP90AA1 | |
| SCHEMBL19231139 | 1.00 | EBP (0.61) | EBPDHCR7S100A4PAX8HSP90AA1 | |
| SCHEMBL18787141 | 1.00 | EBP (0.61) | EBPDHCR7S100A4PAX8HSP90AA1 | |
| SCHEMBL19565417 | 0.96 | EBP (0.55) | EBPDHCR7S100A4PAX8HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113967258-A | FAP-activated therapeutics and uses related thereto | 塔夫茨大学信托人 | 2022-01-25 | — | — | CN | disclosed |
| CN-113956325-A | FAP-activated therapeutics and uses related thereto | 塔夫茨大学信托人 | 2022-01-21 | — | — | CN | disclosed |
| CN-113786495-A | FAP-activated therapeutics and uses related thereto | 塔夫茨大学信托人 | 2021-12-14 | — | — | CN | disclosed |
| CN-106573073-B | FAP-activated therapeutics and uses related thereto | 塔夫茨大学信托人 | 2021-09-28 | — | — | CN | disclosed |